Gan To Kagaku Ryoho
July 2011
The prognosis for patients with brain metastases of small-cell lung cancer is particularly dismal. We present a case of a 47- year-old man diagnosed with multiple brain tumors which, following surgery, were revealed to be metastatic small-cell lung carcinoma through a pathological examination and a subsequent post-operative chest CT. Whole brain irradiation (50 Gy) with ten courses of systemic chemotherapy (carboplatin 200 mg/m2 day 1; etoposide 60 mg/m2 day 1-5) was applied.
View Article and Find Full Text PDFNeurol Med Chir (Tokyo)
September 2010
A 47-year-old man presented with chronic cranial subdural hematomas (SDHs) associated with spinal SDH manifesting as onset of severe lumbago revealed in the follow up for bilateral subdural effusions after trauma. Left chronic cranial SDH was first identified. Two months after evacuation of the left chronic cranial SDH, he complained of severe lumbago.
View Article and Find Full Text PDFAneurysms of the superficial temporal artery are usually traumatic in origin an are pseudoaneurysms. We present a rare case of an idiopathic dissecting aneurysm of the superficial temporal artery in a 40-year-old man without history of trauma. The patient had a pulsatile mass in the left temporal region.
View Article and Find Full Text PDFA 74-year old female was admitted to our hospital due to sudden right hemiparesis. Precontrast brain computed tomography (CT) revealed multiple high-density masses consistent with multiple hemorrhage, and chest CT scan demonstrated a mass in the left lung field without hemorrhage. Follow-up CT showed enlargement of the multiple intracerebral hemorrhages.
View Article and Find Full Text PDFA 37-year-old woman presented with photophobia without visual loss associated with chiasmal compression by an unruptured anterior communicating artery (AcomA) aneurysm. She had suffered progressive photophobia for one year. Neuroimaging indicated an AcomA aneurysm attached to the chiasm.
View Article and Find Full Text PDFA 48-year-old woman presented with simultaneous aneurysmal subarachnoid hemorrhage (SAH) and remote intracerebral hemorrhage manifesting as sudden onset of severe headache, left hemiparesis, and diplopia. Emergent computed tomography revealed localized SAH in the interpeduncular cistern, and a remote brainstem hematoma in the right dorsolateral tegment. Neuroimaging found no signs of vascular anomaly in the brainstem.
View Article and Find Full Text PDFWe report an interesting case of hydrocephalus following traumatic subdural effusion. A 50-year-old male was diagnosed as a traumatic subdural effusion. Three months later, he was transferred to our hospital again because of conscious disturbance and incontinence.
View Article and Find Full Text PDFMedulloblastomas are highly lethal tumors when they recur. Very few patients survive with conventional treatment. This report documents the preliminary study results of a treatment for recurrent medulloblastomas consisting of stereotactic radiation therapy (SRT) with chemotherapy.
View Article and Find Full Text PDFNeurol Med Chir (Tokyo)
October 2005
A 47-year-old man presented with repeated headache and feverishness 3.5 years after undergoing ventriculoperitoneal shunt surgery for normal pressure hydrocephalus secondary to subarachnoid hemorrhage. Abdominal computed tomography revealed that the peritoneal catheter was encased by fibrous tissue and the distal end of the catheter had migrated into the stomach.
View Article and Find Full Text PDFObject: The JC virus is a human neurotropic polyomavirus that causes progressive multifocal leukoencephalopathy and is closely related to simian virus 40. Several recent reports have indicated a possible association between the JC virus and the development of various human brain tumors. The authors examined the presence of JC virus DNA sequences in primary brain tumors in pediatric patients to evaluate the hypothesis that particular brain tumors can arise in the pediatric population as a consequence of infection with the JC virus.
View Article and Find Full Text PDFThrombi, encapsulated hematomas, and granulation tissue are frequently seen in cerebral cavernous malformations (CCMs). We investigated the role that these histological changes play in repeated hemorrhages in CCMs as well as lesion growth, examining specimens of CCMs surgically harvested from 20 patients. The immunohistochemical study included thrombomodulin (TM) and endothelial cell protein C receptor (EPCR), which are important regulators of blood coagulation.
View Article and Find Full Text PDFThe Wilms' tumor gene WT1 was first identified as the gene responsible for a childhood renal tumor, Wilms' tumor. This gene encodes for a zinc finger-containing transcription factor. Although originally identified as a tumor suppressor gene, WT1 is overexpressed in a variety of hematologic malignancies and solid tumors.
View Article and Find Full Text PDFCystic mass lesions in the suprasellar cistern are often associated with neurological deficits, cognitive disorders, and endocrinological impairments. Many surgical approaches are available to treat these mass lesions, but are technically difficult and cannot remove the lesion completely without risking damage to neurological and endocrinological functions due to the proximity to the surrounding structures. Neuroendoscopic transventricular surgery was performed using a ventricular fiberscope for three patients with craniopharyngiomas and two patients with Rathke cleft cysts, with gamma knife radiosurgery for craniopharyngiomas.
View Article and Find Full Text PDFWe examined whole genomic aberrations of biopsied samples from 19 independent glioblastomas by array-based comparative genomic hybridization analysis. The highest frequencies of copy number gains were observed on RFC2 (73.3%), EGFR (63.
View Article and Find Full Text PDFSeveral proteins are known to be markedly expressed in the brain during cerebral ischemia, however the change in protein profiles within the cerebrospinal fluid (CSF) after an ischemic insult has not been fully elucidated. We studied the changes in the CSF proteome in rat transient middle cerebral artery occlusion model. Surface enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry (MS) was used to detect the time-course changes in CSF protein patterns after transient focal brain ischemia.
View Article and Find Full Text PDFCapillary hemangiomas have rarely been reported to develop in the brain or spinal cord. Here we report the histological and immunohistochemical features of ten cases of central nervous system capillary hemangiomas (CNSCH) and compare these to those of lobular capillary hemangioma (LCH) of the skin. CNSCH showed a lobular architecture with lobules that were separated by fibrous tissue septa in six cases.
View Article and Find Full Text PDFNeural stem cells (NSCs) are multipotential progenitor cells that have self-renewal activity. Since the fates of the NSCs in situ depend on their niche containing growth factors and cytokines, we performed surface enhanced laser desorption/ionization time-of flight mass spectrometry (SELDI-TOF-MS) to screen for differentially secreted proteins in conditioned medium of neural stem cells and compared with that of NIH3T3 cells. A 15.
View Article and Find Full Text PDFBiochem Biophys Res Commun
September 2004
Fas (CD95) ligand (FasL) has the ability to induce apoptosis in Fas-expressing glioma cells by binding to Fas. Several molecular species have been designed to be soluble Fas ligands for therapeutic purposes. We successfully constructed a chimeric soluble FasL by fusing an isoleucine zipper motif for self-oligomerization and a FLAG sequence to the extracellular domain of the human Fas ligand (FIZ-shFasL).
View Article and Find Full Text PDFObject: Capillary hemangiomas are benign tumors or tumorlike lesions that originate from blood vessels and have rarely been reported to develop in the brain or spinal cord. The authors summarize the clinical and histological features of capillary hemangiomas of the central nervous system (CNS).
Methods: The clinical features, imaging characteristics, and outcomes in 10 patients with CNS capillary hemangiomas were reviewed.