Subnanomolar Sensitive Stable Isotopic Determination in CO by Tunable Infrared Laser Absorption Spectroscopy.

Oxygen and carbon stable isotope ratios (O/O, C/C, and O/O) of CO have been crucial in helping us understand Earth and planetary systems. These ratios have also been used in medicine for the noninvasive diagnosis of diseases from exhaled breath and for quantifying biochemical or metabolic reactions and in determining the production area of agricultural products. The current method for measuring the stable isotope ratios of CO is primarily gas-source isotope ratio mass spectroscopy (IRMS).

Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain.

The Elongin complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. Elongin is composed of a transcriptionally active A subunit, and two positive regulatory B and C subunits. Although the NH(2)-terminal approximately 120 amino acid region of Elongin A is dispensable for its transcriptional activity in vitro, it shares significant sequence similarity with the NH(2)-terminus of other class of transcription factors SII and CRSP70, suggesting that the NH(2)-terminus mediates interactions important for the regulation of transcription in vivo.

Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3.

The Elongin complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. Elongin is composed of a transcriptionally active A subunit and two small regulatory B and C subunits, the latter binding stably to each other to form a binary complex that interacts with Elongin A and strongly induces its transcriptional activity. To further understand the role of Elongin A in transcriptional regulation by RNA polymerase II, we are attempting to identify Elongin A-related proteins.

Effect of six flavonoid compounds from Ixeris sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils.

Background: Ixeris sonchifolia (Bge.) Hance is an herbal medication used in China as an analgesic.

Methods: The effect of six flavonoid compounds isolated from Ixeris sonchifolia (Bge.