Publications by authors named "Kazunobu Ito"
A 37-year-old woman was admitted to our hospital because of acute respiratory distress. Two weeks previously, amoxapine (75 mg/day) had been administered for the first time. Ten days later she developed a high fever, severe hypoxaemia and pulmonary infiltrates on chest CT, including patchy areas of ground-glass opacity, thickening of the interlobular septae and bronchial walls and pleural effusions.
View Article and Find Full Text PDFBackground: ADAM (a disintegrin and metalloprotease) family members, characterized by a metalloprotease and a disintegrin domain, are membrane-anchored glycoproteins involved in proteolysis and cell adhesion. ADAM8 might have an important role in allergic inflammation. It can cleave a variety of substrates and is a sheddase for VCAM-1 and CD23, the low-affinity IgE receptors.
View Article and Find Full Text PDFRecent studies have strengthened the concept that bronchial asthma and allergic rhinitis are manifestations of an inflammatory process within a continuous airway. This study was performed to compare clinical findings in asthma with or without rhinitis in Japan. Nasal symptoms were present in 99.
View Article and Find Full Text PDFArticle Synopsis
- TARC (Thymus- and activation-regulated chemokine) is a chemokine that attracts Th2 cells, which play a role in immune responses, particularly in eosinophilic pneumonia.
- In a study, TARC levels were found to be significantly higher in the bronchoalveolar lavage (BAL) fluid of eosinophilic pneumonia patients compared to those with other lung diseases or healthy controls.
- There was a strong correlation between TARC levels and Th2 cytokines like IL-5 and IL-13, suggesting that TARC may actively recruit these cells to the lungs, indicating its involvement in the development of eosinophilic pneumonia.