Publications by authors named "Kazumasa Miyatake"

The pain assessment in animals is challenging as they cannot verbally express the site and severity of pain. In this study, we tried a small implantable actimeter, "Nanotag", to monitor spontaneous locomotor activity and body temperature in animals suffering from a chemical-induced rat knee arthritis as compared to naïve and steroid-treated rats. Nanotag could detect the decrease in locomotor activity quickly after the arthritis induction and anti-inflammation analgesic treatment by intra-articular injection of steroid significantly improved locomotor activity.

View Article and Find Full Text PDF

Background: The vancomycin presoaking technique (wherein grafts are treated with a vancomycin solution [VS] for anterior cruciate ligament reconstruction [ACLR]) reduces the infection rate after ACLR. However, the effects of this technique on graft-bone healing have not been fully elucidated.

Purpose: To investigate the effects of vancomycin presoaking on graft-bone healing in a rat ACLR model.

View Article and Find Full Text PDF
Article Synopsis
  • Periacetabular osteotomy (PAO) is a surgical procedure that helps improve hip joint coverage in patients with hip dysplasia to prevent arthritis development, but the effects on 3D acetabular coverage and long-term outcomes are not fully understood.
  • This study examined 46 patients and utilized pre- and post-operative imaging to analyze changes in acetabular coverage and determine factors leading to total hip arthroplasty (THA) and osteoarthritis progression.
  • Results indicated an increase in acetabular coverage after PAO, with a 98% survival rate over 10 years, but highlighted that insufficient superior acetabular coverage post-surgery significantly increased the likelihood of requiring THA and experiencing osteoarthritis progression
View Article and Find Full Text PDF
Article Synopsis
  • This study investigates the time from diagnosis to surgery for osteonecrosis of the femoral head (ONFH) and factors affecting its severity among 2074 cases in Japan from 1997 to 2018.
  • The median time to surgery was found to be 9 months, influenced by whether the patient used alcohol or corticosteroids, and the stage of joint destruction at diagnosis.
  • The study highlights that a large proportion of patients remain untreated for extended periods, but surgery was performed within 9 months for more than half of the patients, indicating the disease's serious impact.
View Article and Find Full Text PDF

Background: Variations in bone morphology in patients with hip osteoarthritis (HOA) can be broadly categorized into three types: atrophic, normotrophic, and hypertrophic. Despite the investigations examining clinical elements, such as bone morphology, pain, and range of motion, our understanding of the pathogenesis of HOA remains limited. Previous studies have suggested that osteophytes typically originate at the interface of the joint cartilage, periosteum, and synovium, potentially implicating synovial mesenchymal stem cells (SMSCs) in the process.

View Article and Find Full Text PDF
Article Synopsis
  • A retrospective study examined osteoporosis-related biomarkers in patients with rapidly destructive coxarthrosis (RDC) versus osteoarthritis (OA) in 398 hip joints undergoing total hip arthroplasty.
  • Findings showed RDC patients were older, had lower albumin levels, and elevated levels of TRACP-5b and total P1NP, with significant differences in the TRACP-5b to total P1NP ratio.
  • The study suggests that higher TRACP-5b levels in early RDC could indicate increased bone resorption, and targeting this biomarker might help slow disease progression.
View Article and Find Full Text PDF
Article Synopsis
  • The study explores how patients with hip osteoarthritis (OA) manage their hip angles during walking to prevent disease progression.
  • Using data from 80 healthy participants and 106 patients with hip OA, researchers analyzed joint movements to assess variability in hip angle stability through various metrics.
  • Results indicated that while OA patients stabilized their hip angles better in the frontal plane during the later stages of walking, they struggled to maintain stability in the sagittal plane, showcasing the influence of whole-body movements on hip angle management.
View Article and Find Full Text PDF

Introduction: Intraoperative periprosthetic fracture, one of the most frequent complications of total hip arthroplasty, is a very important factor that affects rehabilitation, hospitalization time, and cost of treatment. Osteoporosis is common in total hip arthroplasty patients and likely contributes to the increasing incidence of periprosthetic fracture. Despite this awareness, preoperative and postoperative osteoporosis evaluations remain insufficient.

View Article and Find Full Text PDF

Background: Intra-articular injection of C-type natriuretic peptide (CNP) at the acute inflammatory stage suppressed fibrotic changes in the infrapatellar fat pad (IFP), articular cartilage degeneration, and persistent pain in a monoiodoacetic acid (MIA)-induced rat knee arthritis model. In this study, we administered CNP during the inflammation subsiding period to evaluate CNP effectiveness in knees with osteoarthritis (OA) pathology.

Methods: 20 male Wistar rats were randomly divided into two groups.

View Article and Find Full Text PDF

Fibrosis of the infrapatellar fat pad (IFP) occurs after knee joint surgery or during knee osteoarthritis (KOA) and causes persistent pain and limited mobility. Previous studies demonstrated that treating IFP fibrosis alleviated pain in animal models. In this study, we examined the effects of hyaluronic acid (HA) sheet transplantation on IFP fibrosis and articular cartilage degeneration in a monoiodoacetic acid (MIA) rat arthritis model (95 male rats).

View Article and Find Full Text PDF
Article Synopsis
  • Osteoporosis is prevalent among patients undergoing total hip arthroplasty (THA), impacting surgery outcomes and implant survival rates; the study aimed to assess the prevalence and treatment of osteoporosis in these patients.
  • In a retrospective analysis of 398 hip joints, findings showed that 8.8% had hip osteoporosis and 4.5% had spinal osteoporosis, while only 22.1% received pharmacological treatment for the condition.
  • The study revealed that treated patients exhibited significantly lower levels of the biomarker TRACP-5b compared to untreated patients, suggesting effective treatment may reduce the risk of postoperative complications.
View Article and Find Full Text PDF

Tissue-residing mesenchymal stromal/stem cells (MSCs) have multipotent characteristics that are important for adult tissue homeostasis and tissue regeneration after injury. We previously reported that fibroblastic cells isolated from the synovial membrane in the knee joint give rise to cells with MSC characteristics in a two-dimensional culture. To explore the molecular mechanisms underlying these hyperplastic properties, we performed time-course surface antigen expression analyses during culture.

View Article and Find Full Text PDF
Article Synopsis
  • Nerve palsy following total hip arthroplasty (THA) can significantly affect patients, and this study focuses on femoral nerve palsy (FNP) related to the modified Watson-Jones surgical approach.
  • The research aimed to identify risk factors for FNP, particularly the relationship between short stature and a shorter distance from the femoral nerve to the anterior acetabular edge (dFN).
  • Conducted at a university hospital from 2016 to 2020, the study analyzed data from 676 THA procedures, assessing various patient factors to understand the incidence and possible causes of FNP post-surgery.
View Article and Find Full Text PDF

Objectives: IL1β enhances proliferation of synovial mesenchymal stem/stromal cells (synMSCs) although they don't express its receptor, IL1R1/CD121a, on the cell surface. This study was aimed to elucidate the underlying mechanisms of IL1β-mediated growth promotion.

Methods: Human synMSCs were isolated from the suprapatellar synovial membrane.

View Article and Find Full Text PDF

Purpose:  The purpose of this study was to compare clinical outcomes between revision anterior cruciate ligament reconstruction (ACLR) using a bone-patellar tendon-bone (BPTB) autograft and that using a double-bundle hamstring tendon (HT) autograft.

Methods:  Consecutive cases of revision ACLRs were reviewed. The Lysholm knee scale and Knee Osteoarthritis Outcome Score (KOOS) were recorded at the final follow-up.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigated the risk of periprosthetic bone fragility and fractures following cementless total hip arthroplasty (THA), focusing on how stress shielding affects patients.* -
  • Researchers reviewed the medical records of 1,062 patients who underwent cementless THA, finding that 8 cases (0.8%) were diagnosed with periprosthetic femur fractures (PPFF).* -
  • The long-term survival rates showed that 99.2% remained fracture-free at 10 years, and 97.6% at 16 years, with no significant survival difference based on the severity of stress shielding.*
View Article and Find Full Text PDF
Article Synopsis
  • A study was conducted to compare the wear rates and osteolysis incidence of two types of second-generation annealed highly cross-linked polyethylene (HXLPE) used in total hip arthroplasties over a minimum of 5 years.
  • The research reviewed 257 cases, with 208 patients followed for an average of 6.1 years, and utilized 32mm delta ceramic implants for two types of HXLPE labeled as X3 and E1.
  • Results indicated no significant differences in wear rates (0.057mm/year for X3 and 0.054mm/year for E1) or osteolysis incidence between the two groups, alongside similar demographic and clinical characteristics.
View Article and Find Full Text PDF

Background: Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are promising candidates for tissue regeneration therapy. However, the therapeutic efficacy of MSC-EVs for meniscus regeneration is uncertain, and the mechanisms underlying MSC-EV-mediated tissue regeneration have not been fully elucidated. The aims of this study were to evaluate the therapeutic efficacy of intra-articular MSC-EV injection in a meniscus defect model and elucidate the mechanism underlying MSC-EV-mediated tissue regeneration via combined bioinformatic analyses.

View Article and Find Full Text PDF

The study aimed to improve the long-term outcomes of open-wedge high tibial osteotomy (OWHTO); procedures combining OWHTO aimed at neutral alignment and arthroscopic centralization for meniscal extrusion have been introduced. The present study evaluated short-term patient-reported outcome measures; namely, the patient subjective satisfaction scores and Numeric Rating Scale (NRS) for walking pain after OWHTO aimed at neutral alignment with and without arthroscopic centralization for an extruded medial meniscus. A retrospective review of 50 primary OWHTO patients was conducted.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to determine how different body positions (supine vs. lateral) during total hip arthroplasty (THA) affect the alignment of tapered wedge stems post-surgery.
  • Researchers analyzed data from 242 THA procedures, measuring the differences in stem anteversion and alignment using pre- and postoperative CT scans.
  • Results showed that while the supine position had a stronger correlation between femoral and stem anteversion, the lateral position allowed for better neutral alignment in the sagittal plane, suggesting that surgeons should consider these factors when choosing surgical positions.
View Article and Find Full Text PDF

Background: Biological processes after anterior cruciate ligament reconstruction (ACLR) is crucial for recovery. However, alterations in the of synovial fluid cell population during the acute phase following ACLR and the relationship between these cells and postoperative pain is unclear. The goal of this study was to reveal alterations in synovial fluid cell population during the acute phase following ACLR and relationship between postoperative pain and proportion of synovial fluid cells.

View Article and Find Full Text PDF
Article Synopsis
  • Neurovascular injury is a significant concern in total hip arthroplasty (THA), and this study aimed to examine how body position (supine vs. lateral) affects neurovascular geography around the hip joint using MRI.
  • A total of 15 healthy volunteers had their hips scanned in both positions, focusing on distances between the acetabular edges and major nerves/vessels like the femoral nerve and artery.
  • Results indicated that in the lateral position, these structures are positioned further away from the acetabular edges compared to the supine position, suggesting a lower risk of neurovascular injury during THA when performed laterally.
View Article and Find Full Text PDF

Purpose: Short stems have recently become popular in total hip arthroplasty. Previous studies aimed at elucidating the efficacy of short stems did not eliminate the influence of other factors aside from stem length. This study aimed to evaluate the usefulness of short stems compared with that of standard-length stems that have the same proximal morphology, surface coating, and material.

View Article and Find Full Text PDF
Article Synopsis
  • This study investigates the occurrence of tensor fascia lata (TFL) muscle atrophy due to superior gluteal nerve injury in patients undergoing total hip arthroplasty using a specific surgical approach.
  • Out of 164 patients analyzed, only 8% showed signs of TFL atrophy post-surgery, with higher body mass index (BMI) linked to this condition.
  • The findings suggest that while TFL atrophy is relatively uncommon, patients with higher BMI are at greater risk and that careful surgical techniques are necessary to prevent potential nerve injuries.
View Article and Find Full Text PDF

Previous studies have shown better clinical outcomes after total hip arthroplasty (THA) compared to hemiarthroplasty (HA) for displaced femoral neck fracture. However, few studies have focused on the surgical risks of the two procedures. Therefore, we investigated the perioperative complications of HA and THA in femoral neck fracture, using a large nationwide inpatient database.

View Article and Find Full Text PDF