Ventricular arrhythmia induced by sodium channel blocker in patients with Brugada syndrome.

Objectives: We administered pilsicainide chloride, a class Ic pure sodium channel blocker, to patients with Brugada syndrome (BS) and evaluated the occurrence of ventricular arrhythmia (VA) and T-wave alternans (TWA).

Background: Ventricular arrhythmia and TWA are sometimes induced by a sodium channel blocker challenge test in BS patients, but the significance of the induced VA and TWA is not known.

Methods: Pilsicainide was administered to 65 patients with BS (10 symptomatic and 55 asymptomatic patients), and the occurrence of VA, TWA, and change of electrocardiogram were evaluated.

Atrial fibrillation and atrial vulnerability in patients with Brugada syndrome.

Objectives: We sought to study atrial vulnerability in patients with Brugada syndrome.

Background: Atrial fibrillation (AF) often occurs in patients with Brugada syndrome, but atrial vulnerability in Brugada syndrome has not been evaluated.

Methods: The patient group consisted of 18 patients with Brugada syndrome.