Publications by authors named "Kazuma Yoshioka"
FEBS Open Bio
October 2024
Article Synopsis
- Protein ubiquitination is crucial for various biological processes, including protein degradation and neural functions, with USP46 as a key deubiquitinase highly expressed in the brain.
- A mutation (ΔK92) in USP46 is linked to reduced depressive behaviors in mice, yet the detailed mechanisms of its neural function regulation remain unclear.
- Using advanced genome editing and biotinylation techniques, researchers identified 286 potential interaction partners of USP46, highlighting a significant connection between USP46 and centrosome-related proteins, suggesting a role in centrosome regulation that is separate from protein stability.
