Publications by authors named "Kazuma Nishisaka"
Clin Rheumatol
November 2024
Article Synopsis
- Three cases of eosinophilic granulomatosis with polyangiitis (EGPA) are discussed, where patients relapsed with eosinophilic sinusitis while on mepolizumab (MPZ) maintenance therapy, despite not having elevated peripheral eosinophil counts.
- * Relapses included symptoms like nasal obstruction and biopsies showed eosinophilic infiltration, indicating localized inflammation rather than systemic issues.
- * The study emphasizes that IL-5 inhibitors may not fully address eosinophilic sinusitis due to local factors (like IL-4), suggesting the need for more research to improve treatment strategies for EGPA.*
