Publications by authors named "Kazuma Kawahara"
The global incidence of nontuberculous mycobacterial pulmonary disease (NTM-PD) is increasing. The primary aim of pharmacotherapeutic treatment for NTM-PD is to achieve negative bacterial conversion, but this goal is challenging, especially in cases with poor prognosis factors. Moreover, recurrence frequently occurs following successful treatment.
View Article and Find Full Text PDFWhy the recently discovered nematode Caenorhabditis inopinata differs so greatly from its sibling species Caenorhabditis elegans remains unknown. A previous study showed that C. inopinata has more transposable elements (TEs), sequences that replicate and move autonomously throughout the genome, potentially altering the expression of neighboring genes.
View Article and Find Full Text PDFBackground: In the treatment of patients with nontuberculous mycobacterial pulmonary disease (NTM-PD), pulmonary rehabilitation (PR) has been recommended as a non-pharmacological therapy. However, no study has validated the combination of chemotherapy and PR in this context. This study investigated the effect of chemotherapy and supervised PR on health-related quality of life (HRQoL) and physical function in NTM-PD patients.
View Article and Find Full Text PDFRoot water uptake depth and its temporal variation are important determinants of tree mortality, resource partitioning and drought resistance; however, their effects on tropical trees remain poorly understood. In this study, we investigated interspecific differences in water uptake depth and its temporal variation using stable isotope analysis and examined the relationships between water uptake depth and aboveground traits in a humid aseasonal tropical rainforest in Borneo. Species-specific differences in water uptake depth were examined for six dominant dipterocarp species.
View Article and Find Full Text PDFBackground: Patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD) have impaired exercise capacity, but the underlying factors are unknown. We investigated the characteristics of patients with NTM-PD and impaired exercise capacity.
Methods: In total, 149 patients with NTM-PD participated in this study.
Background: The effect of chronic sputum (CS) symptoms on health-related quality of life (HRQOL) in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) has not been studied. The aim of this study was to clarify the differences in the clinical characteristics of NTM-PD patients with and without CS and to investigate the effect of CS on HRQOL.
Methods: This cross-sectional study included patients with NTM-PD who were prescribed pulmonary rehabilitation at the Fukujuji Hospital from March 2016 to June 2019.
The experience and causes of pain in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) have not been clarified.This study aimed to determine the prevalence and severity of bodily pain (BP) in patients with NTM-PD. We also investigated the clinical indicators that contribute to pain.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to evaluate depressive symptoms in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) using two common screening tools: CES-D and HADS-D.
- - Findings indicated a prevalence of depressive symptoms at 37.9% with CES-D and 26.3% with HADS-D, highlighting significant differences in results between the two tools.
- - Cough was identified as a key predictor of depressive symptoms, reflecting the need for awareness and interventions to address mental health in NTM-PD patients.
Article Synopsis
- * Researchers analyzed medical records of 81 patients, finding significant correlations between the SGRQ and LCQ scores, indicating both questionnaires can reflect aspects of HRQOL in NTM-LD.
- * The LCQ may be particularly valuable for assessing HRQOL as it focuses on cough-related symptoms, and key factors like lung function and radiological scores impact scores from both HRQOL assessments.