Publications by authors named "Kazuki Yatabe"
In a proof-of-concept study, a mechano-chromic hydrogel was synthesized here, via chemoenzymatic click conjugation of fluorophore-labeled fibronectin into a synthetic hydrogel co-polymers (i.e., poly-N-isopropylacrylamide/polyethylene glycol).
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- A novel small photo-crosslinker was created to study the binding site of a specific peptide that contains a fluoroprobe, using a process that involves Suzuki coupling.
- The crosslinker is designed to act as a bioisostere of the fluoroprobe and can be activated under a standard UV light, turning the target protein fluorescent with a significant Stokes-shift.
- The binding site of the peptide was identified using techniques like SDS-PAGE for fluorescence imaging and MALDI-TOF-MS/MS for further analysis.