Design of Multi-Target drugs of HDACs and other Anti-Alzheimer related Targets: Current strategies and future prospects in Alzheimer's diseases therapy.

Alzheimer disease (AD) is the most prevalent form of dementia that develops spontaneously in the elderly. It's worth mentioning that as people age, the epigenetic profile of the central nervous system cells changes, which may speed up the development of various neurodegenerative disorders including AD. Histone deacetylases (HDACs) are a class of epigenetic enzymes that can control gene expression without altering the gene sequence.

Comparison in Repetitions to Failure Between Concentric-Only and Eccentric-Only Dumbbell Arm Curl Exercise at Four Different Relative Intensities.

Shibata, K, Yamaguchi, T, Takizawa, K, and Nosaka, K. Comparison in repetitions to failure between concentric-only and eccentric-only dumbbell arm curl exercise at four different relative intensities. J Strength Cond Res 37(9): 1754-1760, 2023-The repetitions to failure (RF) were compared between concentric-only (CON) and eccentric-only (ECC) arm curl exercise for different intensities based on CON and ECC 1 repetition maximum (1RM), respectively, with 2 different inter-repetition rests.

Warm-Up Intensity and Time-Course Effects on Jump Height under Cold Conditions.

With this study, we aimed to investigate the effects of different warm-up intensities on counter-movement jump (CMJ) performance over time under cold conditions. Eleven male collegiate athletes volunteered. The participants performed high-intensity warm-up (HWU) at 80% VO2max and moderate-intensity warm-up (MWU) at 60% VO2max for 15 min on a bicycle ergometer in a laboratory room at 10 °C.

Warm-Up Intensity and Time Course Effects on Jump Performance.

Jump performance is affected by warm-up intensity and body temperature, but the time course effects have not been thoroughly investigated. The purpose of this study was to investigate time course effects on jump performance after warm-up at different intensities. Nine male athletes (age: 20.

Effect of General Warm-Up Plus Dynamic Stretching on Endurance Running Performance in Well-Trained Male Runners.

: The purpose of this study was to compare the acute effects of general warm-up (GWU) and GWU plus dynamic stretching (GWU + DS) on endurance running performance in well-trained male runners. : The endurance running performances of eight well-trained long-distance male runners were assessed on a treadmill after 2 types of intervention for 5 min after running on the treadmill at a velocity equivalent to 70% maximal oxygen uptake (V̇Omax) in each athlete for 15 min. The interventions were GWU and GWU + DS.

Comparison Between Two Volume-Matched Squat Exercises With and Without Momentary Failure for Changes in Hormones, Maximal Voluntary Isometric Contraction Strength, and Perceived Muscle Soreness.

Shibata, K, Takizawa, K, Tomabechi, N, Nosaka, K, and Mizuno, M. Comparison between two volume-matched squat exercises with and without momentary failure for changes in hormones, maximal voluntary isometric contraction strength and perceived muscle soreness. J Strength Cond Res 35(11): 3063-3068, 2021-The present study compared 2 squat exercises with and without momentary failure (MF) for changes in blood hormones, maximal voluntary isometric contraction (MVC) strength, and perceived muscle soreness (SOR).

Effects of Prolonging Eccentric Phase Duration in Parallel Back-Squat Training to Momentary Failure on Muscle Cross-Sectional Area, Squat One Repetition Maximum, and Performance Tests in University Soccer Players.

Shibata, K, Takizawa, K, Nosaka, K, and Mizuno, M. Effects of prolonging eccentric phase duration in parallel back-squat training to momentary failure on muscle cross sectional area, squat one repetition maximum, and performance tests in university soccer players. J Strength Cond Res 35(3): 668-674, 2021-This study aimed to compare 2 squat training programs repeated until momentary failure with different eccentric phase duration (2 seconds vs.

Effects of 3-Week Work-Matched High-Intensity Intermittent Cycling Training with Different Cadences on VO in University Athletes.

The aim of this study is to clarify the effects of 3-week work-matched high-intensity intermittent cycling training (HIICT) with different cadences on the VO of university athletes. Eighteen university athletes performed HIICT with either 60 rpm ( = 9) or 120 rpm ( = 9). The HIICT consisted of eight sets of 20 s exercise with a 10 s passive rest between each set.

Synthesis of Chiral Homoallylic Nitriles by Iridium-Catalyzed Allylation of Cyanoacetates.

A synthesis of chiral homoallylic nitriles by the iridium-catalyzed allylation of cyanoacetates followed by Krapcho demethoxycarbonylation has been developed. A wide range of homoallylic nitriles were obtained with a high enantioselectivity (>95-99% ee). These compounds are useful chiral building blocks because further synthetic elaboration starting from a nitrile or terminal alkene is possible.

Warm-Up Exercises May Not Be So Important for Enhancing Submaximal Running Performance.

Takizawa, K, Yamaguchi, T, and Shibata, K. Warm-up exercises may not be so important for enhancing submaximal running performance. J Strength Cond Res 32(5): 1383-1390, 2018-The purpose of this study was to determine an appropriate warm-up intensity for enhancing performance in submaximal running at 90% vV[Combining Dot Above]O2max (it assumes 3,000-5,000 m in track events).

Evidence for an amphibian sixth digit.

Introduction: Despite the great diversity in digit morphology reflecting the adaptation of tetrapods to their lifestyle, the number of digits in extant tetrapod species is conservatively stabilized at five or less, which is known as the pentadactyl constraint.

Results: We found that an anuran amphibian species, Xenopus tropicalis (western clawed frog), has a clawed protrusion anteroventral to digit I on the foot. To identify the nature of the anterior-most clawed protrusion, we examined its morphology, tissue composition, development, and gene expression.

Acute Effect of Dynamic Stretching on Endurance Running Performance in Well-Trained Male Runners.

The purpose of this study was to clarify the acute effect of dynamic stretching (DS) on relative high-intensity endurance running performance. The endurance running performances of 7 well-trained middle- or long-distance male runners were assessed on a treadmill after 2 types of pretreatment. The pretreatments were nonstretching (NS) and DS treatment.

Postural stabilization by trunk tightening force generated by passive power-assist device.

We are developing a passive power-assist supporter called Smart Suit Lite, which is a compact and lightweight power-assist device that utilizes the restoring force of elastic belts. Smart Suit Lite is designed not only to support muscles but also to stabilize the torso similarly to a corset. However, because a corset is always tight around the waist, negative effects caused by long-term use has been pointed out.

A rice diet is associated with less fat synthesis/accumulation than a bread diet before exercise therapy.

For effective exercise therapy after waking up, we focused on the staple food in diet therapy, and compared rice and bread diets. The subjects were 10 healthy college male students. After fasting for 12 h or more from the previous day, the subjects had breakfast consisting of rice (protein, 6.