Enantio- and diastereoselective asymmetric allylic alkylation catalyzed by a planar-chiral cyclopentadienyl ruthenium complex.

We report asymmetric allylic alkylation of allylic chloride with β-diketones as the prochiral carbon nucleophiles using a planar-chiral Cp'Ru catalyst. The reaction proceeds under mild conditions; the resulting chiral products containing vicinal tertiary stereocenters are obtained with high regio-, diastereo-, and enantioselectivities. These chiral products can then be transformed into a chiral diol by controlling the four stereocentres.

[Metastasis of uterine leiomyosarcoma to the pancreas--usefulness and limitations of EUS-FNA].

A woman in her 60's presented with a tumor of the pancreatic body. Pan-hysterectomy had been performed under a diagnosis of uterine leiomyoma 11 years previously. A sample obtained by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) revealed the histopathological proliferation of spindle-shaped bundles of atypical cells, and immunohistochemical staining demonstrated that these cells were positive for KIT.

[Histological diagnosis of Helicobacter pylori using biopsy specimens].

Helicobacter pylori(H. pylori) are an organism that can be confidently recognized by histology. Using histological specimens, we can both identify infection and assess pathological condition associated with H.