Effects of weight loss from oral semaglutide administration on cardiometabolic risk factors in Japanese patients with type 2 diabetes: a retrospective analysis using propensity score matching.

Background: Obesity is increasingly being recognized as a chronic disease that exacerbates type 2 diabetes and its related complications. Oral semaglutide, a novel glucagon-like peptide-1 (GLP-1) receptor agonist, has demonstrated efficacy in weight loss and diabetes control in Western populations. However, in real-world clinical practice, its effectiveness in Japanese patients, who typically exhibit a leaner phenotype and unique genetic susceptibilities affecting insulin secretion, remains unclear.

Efficacy and safety of a telemedicine system in subjects with gestational diabetes mellitus (TELEGLAM): Study protocol for a randomized controlled trial.

Background: Strict glycemic control is important to prevent perinatal complications in patients with gestational diabetes mellitus (GDM). Patients often require insulin injection, and frequent hospital visits are necessary to adjust the dose of insulin, which is considered burdensome for pregnant patients. Telemedicine may reduce the burden of hospital visits, and previous studies have reported its safety in GDM patients.

Time in range correlates glycated albumin measured immediately after 2 weeks of continuous glucose monitoring.

Aims: Time in range (TIR), an index of glycemic control and also blood glucose fluctuation, obtained from continuous glucose monitoring (CGM), has been increasing its importance along with the spread of CGM in recent years. For a while, glycated albumin (GA) has been also used as a glycemic control index during about 2-weeks in routine clinical practice. It has not yet been confirmed under optimal condition whether TIR and GA correlates.

Circumstances of La, Eu, Dy, and Yb Cations Intercalated via Ion Exchange in γ-Zirconium Phosphate.

Both α- and γ-zirconium phosphate were examined for use as ion exchangers for recovery of rare earth elements. Trivalent rare earth elements can be partially substituted for protons in the interlayer space, and γ-zirconium phosphate shows a much better ion exchange competency than α-zirconium phosphate. The exchanged cation of the rare earth elements might be related to different amounts of oxygen from P-OH and HO, and these rare earth elements were thus positioned at a different separations from the zirconium phosphate layer.

Characterization of clinical isolates of Gordonia species in Japanese clinical samples during 1998-2008.

During 1998-2008, there were 31 strains of Gordonia species isolated from clinical specimens in our laboratory. Our identification of the 31 strains of Gordonia species showed that major pathogenic Gordonia species in Japan were classifiable, respectively into 14 and 13 strains of Gordonia sputi and Gordonia bronchialis. The four remaining strains were identified as three Gordonia species: G.

Nagelamides Q and R, novel dimeric bromopyrrole alkaloids from sponges Agelas sp.

Two new dimeric bromopyrrole alkaloids, nagelamides Q (1) and R (2), have been isolated from Okinawan marine sponges of the genus Agelas (SS-1134 and SS-956, respectively), and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide Q (1) is a rare dimeric bromopyrrole alkaloid possessing a pyrrolidine ring, while nagelamide R (2) is the first bromopyrrole alkaloid having an oxazoline ring. Nagelamides Q (1) and R (2) showed antimicrobial activity.

Tyrokeradines A and B, new bromotyrosine alkaloids with an imidazolyl-quinolinone moiety from a verongid sponge.

Two new bromotyrosine alkaloids, tyrokeradines A (1) and B (2), with an imidazolyl-quinolinone moiety have been isolated from an Okinawan marine sponge of the order Verongida. The structures of 1 and 2 were elucidated on the basis of spectroscopic data.

Halichonadin F and the Cu(I) complex of halichonadin C from the sponge Halichondria sp.

A new sesquiterpenoid with an aromadendrane skeleton, halichonadin F (1), and the Cu(I) complex of haliconadin C (2) were isolated from a marine sponge Halichondria sp., and the structures and relative stereochemistries of 1 and the complex of 2 were elucidated on the basis of spectroscopic data and chemical methods.