Publications by authors named "Kazuhiro Shiga"
Traumatic asphyxia (TA) is a rare condition due to severe crush injury to the upper abdomen or chest region. Elevated intrathoracic pressure causes impaired venous return, which damages the small vessels. Consciousness is reportedly lost in many TA cases.
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- * Results showed that while patients receiving IVIgG were generally more severely ill and had higher ICU mortality, the overall in-hospital mortality rates were similar between those treated with IVIgG and those who were not.
- * The final analysis indicated that IVIgG administration did not significantly influence ICU or in-hospital mortality, suggesting it may not be an effective adjunctive treatment for sepsis in this context.
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- Supplemental doses of antithrombin (AT) are commonly used in Japan to treat sepsis-induced disseminated intravascular coagulation (DIC), but the evidence supporting their effectiveness is limited.
- A large retrospective study analyzed data from 3,195 patients, finding a statistically significant association between AT supplementation and lower in-hospital mortality rates for patients with DIC, although further analyses questioned the strength of this link.
- The study concluded that AT supplementation may help reduce mortality in sepsis-induced DIC, but the evidence is not definitive, and while patients needing AT had more transfusions, they did not experience increased severe bleeding complications.
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- * The average age of the patients was 70 years, and their health status, measured by the Acute Physiology and Chronic Health Evaluation II score, indicated a moderate level of severity.
- * Survival rates were estimated at 73.6% and 56.3% for patients at 28 days and 90 days post-ICU admission, respectively.*
Aim: This study investigated the value of regional cerebral oxygen saturation (rSO2) monitoring upon arrival at the hospital for predicting post-cardiac arrest intervention outcomes.
Methods: We enrolled 1195 patients with out-of-hospital cardiac arrest of presumed cardiac cause from the Japan-Prediction of Neurological Outcomes in Patients Post-cardiac Arrest Registry. The primary endpoint was a good neurologic outcome (cerebral performance categories 1 or 2 [CPC1/2]) 90 days post-event.
Aim: Our study aimed at filling the fundamental knowledge gap on the characteristics of regional brain oxygen saturation (rSO2) levels in out-of-hospital cardiac arrest (OHCA) patients with or without return of spontaneous circulation (ROSC) upon arrival at the hospital for estimating the quality of cardiopulmonary resuscitation and neurological prognostication in these patients.
Methods: We enrolled 1921 OHCA patients from the Japan - Prediction of Neurological Outcomes in Patients Post-cardiac Arrest Registry and measured their rSO2 immediately upon arrival at the hospital by near-infrared spectroscopy using two independent forehead probes (right and left). We also assessed the percentage of patients with a good neurological outcome (defined as cerebral performance categories 1 or 2) 90 days post cardiac arrest.
PKNs form a subfamily of the AGC serine/threonine protein kinases, and have a catalytic domain homologous with that of PKC (protein kinase C) in the C-terminal region and three characteristic ACC (antiparallel coiled-coil) domain repeats in the N-terminal region. The preferred peptide phosphorylation motif for PKNs determined by a combinatorial peptide library method was highly similar to that of PKCs within a 10-amino-acid stretch. Previously reported PKN inhibitory compounds also inhibit PKCs to a similar extent, and no PKN selective inhibitors have been commercially available.
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