Publications by authors named "Kazuhiro Ohnaru"

Article Synopsis
  • - The ACTIVE-J trial demonstrated that daily subcutaneous injections of 80 μg abaloparatide significantly increased bone mineral density (BMD) in Japanese patients with osteoporosis at high fracture risk.
  • - An analysis of hip geometry and biomechanical properties using dual-energy X-ray absorptiometry (DEXA) scans showed substantial improvements in various bone structural parameters after 78 weeks of abaloparatide treatment compared to placebo.
  • - Key findings included increased cortical thickness and volumetric BMD at the hip, alongside a reduced buckling ratio, indicating a lower risk of fractures and reinforcing the potential benefits of abaloparatide for osteoporosis management.
View Article and Find Full Text PDF

Purpose: This study compared differences in trabecular bone architecture and strength caused by jump and running exercises in rats.

Methods: Ten-week-old male Wistar rats (n=45) were randomly assigned to three body weight-matched groups: a sedentary control group (CON, n=15); a treadmill running group (RUN, n=15); and a jump exercise group (JUM, n=15). Treadmill running was performed at 25 m/min without inclination, 1 h/day, 5 days/week for 8 weeks.

View Article and Find Full Text PDF

Introduction: There are patients with lumbar disc herniation (LDH) having contralateral sciatic symptoms although the mechanisms of this clinical feature are still not well understood. The purpose of this study was to investigate these mechanisms by microendoscopic findings.

Methods: Patients were performed microendoscopic surgery using over-the-top approach (ME-OTT), with laminoplasty, extirpation of herniation, and observation of the contralateral nerve root.

View Article and Find Full Text PDF

Swimming is generally considered ineffective for increasing bone mass in humans, at least compared with weight-bearing sports. However, swimming exercise has sometimes been shown to have a strong positive effect on bone mass in small animals. This study investigated the effects of swimming on bone mass, strength, and microarchitecture in ovariectomized (OVX) rats.

View Article and Find Full Text PDF

Substantial evidence from animal studies indicates that jumping increases bone mass and strength. However, most studies have focused on the take-off, rather than the landing phase of jumps. Thus, we compared the effects of landing and upward jump impact on trabecular bone mass and microarchitecture.

View Article and Find Full Text PDF

Geometry of the proximal femur is one determinant of fracture risk, and can be analyzed by a simple method using dual-energy X-ray absorptiometry (DXA). The aim of the present study was to investigate the accuracy of hip structural analysis (HSA) using clinical data in postmenopausal Japanese women. A total of 184 postmenopausal women aged 51-88 years (mean, 70.

View Article and Find Full Text PDF

Three-dimensional femoral trabecular architecture was investigated in tail-suspended young growing rats and the effects of jump exercise during the period of tail-suspension were also examined. Eight-week-old male Wistar rats (n = 24) were randomly assigned to three body weight-matched groups: a tail suspended group (SUS, n = 8); a sedentary control group (CON, n = 8) and rats primed with jump exercise during the period of tail suspension (JUM, n = 8). The jump exercise protocol consisted of 30 jumps/day, five days/week with a 40 cm jump height.

View Article and Find Full Text PDF

Techniques in bone densitometry have made remarkable progress in the past quarter-century and are now widely used in the daily practice of osteoporosis. Since the skeletal site and the method of measurement differ among the type of equipments, several types are adopted to suit the situation of each medical institute. Central DXA is used to provide a thorough examination of osteoporosis in large hospitals, whereas in general clinics the radial DXA or radiographic photodensitometry of metacarpus is mainly used.

View Article and Find Full Text PDF

High-impact exercise is considered to be very beneficial for bones. We investigated the ability of jump exercise to restore bone mass and structure after the deterioration induced by tail suspension in growing rats and made comparisons with treadmill running exercise. Five-week-old male Wistar rats (n = 28) were randomly assigned to four body weight-matched groups: a spontaneous recovery group after tail suspension (n = 7), a jump exercise group after tail suspension (n = 7), a treadmill running group after tail suspension (n = 7), and age-matched controls without tail suspension or exercise (n = 7).

View Article and Find Full Text PDF