Publications by authors named "Kazuhide Takeshita"
Article Synopsis
- - The study investigates genetic mutations in the RAS/RAF/MEK/ERK pathway that are linked to similar genetic disorders, specifically Noonan syndrome, Costello syndrome, and cardio-facio-cutaneous syndrome.
- - Researchers analyzed genetic samples from five patients (three with Noonan syndrome and two with Costello/Cardio-facio-cutaneous syndromes) and discovered significant mutations in PTPN11 and SOS1 genes.
- - Key findings include a rare PTPN11 mutation in a Noonan syndrome patient and a novel SOS1 mutation in a Costello/Cardio-facio-cutaneous patient, highlighting the intricate relationship between genetic mutations and the clinical features of these overlapping syndromes.
We previously reported that low-frequency electric cortical stimulation (LFECS) directly applied to the epileptic focus by means of subdural electrodes decreased the number of interictal epileptiform discharges in patients with intractable partial epilepsy. In the present study, LFECS was applied to the epileptic foci directly in four patients with medically intractable partial epilepsy through subdural electrodes and evaluated its effect on the number of interictal epileptiform discharges as well as simple partial seizures. We used alternating electric current of 0.
View Article and Find Full Text PDFThe purpose of this study was to clarify the neurophysiologic basis of oromotor deficits in a patient with atypical rolandic epilepsy. We investigated magnetoencephalographic analysis of rolandic discharges with right predominance before and during clonazepam therapy. Before clonazepam administration, current sources of rolandic discharges were broadly distributed in the secondary sensory cortex, superior temporal gyrus, and parietal association area in addition to hand and orofacial division of the primary somatosensory cortex.
View Article and Find Full Text PDFThe authors describe the neuropsychological development of a 10-year-old boy with Noonan syndrome. The subject's IQ showed normal intelligence, although there was a discrepancy between verbal and performance IQs. Visual perception was delayed, with clumsiness and inattention affecting his performance.
View Article and Find Full Text PDFIn order to explore human cortical areas involved in active attention toward a somatosensory modality, somatosensory evoked cortical magnetic fields were recorded in ten healthy adults with a 122-channel whole-head magnetometer while the subjects performed the selective attention task. Two kinds of stimulus modality, somatosensory and auditory, were presented independently in the same session. For the somatosensory modality, a randomized sequence of strong (P=0.
View Article and Find Full Text PDFPurpose: This study was conducted to investigate the effect of low-frequency electric cortical stimulation on epileptic focus in humans.
Methods: We stimulated the epileptic focus in a patient with medically intractable mesial temporal lobe epilepsy (MTLE) by means of subdural electrodes and evaluated the change in the number of interictal epileptiform discharges. We used biphasic electric current of 0.