Publications by authors named "Kazuhide Inage"
Overview Of Literature: There are no established treatments for low back pain. Conventional treatments include physiotherapy and pharmacological treatments, such as non-steroidal anti-inflammatory drugs (NSAIDs). Recently, analgesics with mechanisms of action different from those of NSAIDs have emerged.
View Article and Find Full Text PDFBackground: Patients with residual adolescent idiopathic scoliosis (AIS) and thoracolumbar/lumbar curves may present with progression after cessation of growth, with lateral translation as a major risk factor. Nonetheless, radiographic predictors and underlying mechanisms remain indefinite. This study aimed to determine these radiographic predictors and structural mechanisms in patients with residual AIS.
View Article and Find Full Text PDFDiclofenac etalhyaluronate (DF-HA) sustained diclofenac release with the effects of hyaluronic acid (HA), offering long-term analgesia in osteoarthritis. In this study, the effects of DF-HA on pain improvement and osteoarthritis were evaluated in a rat knee monoiodoacetate-induced osteoarthritis model compared to HA. Eight rats per group had been injected with monoiodoacetate (2.
View Article and Find Full Text PDFObjective: The objective of this study was to determine whether a reduction in the retrocrural space (RCS) area is a risk factor for postoperative ileus (POI) in patients with adult spinal deformity (ASD) treated with spinal corrective surgery.
Methods: In total, 100 patients (mean age 67.5 ± 8.
Introduction: Platelet-rich plasma obtained by centrifuging peripheral blood can promote osteogenesis owing to its abundant growth factors but has drawbacks, including rapid growth factor loss and inconsistent effects depending on donor factors. To overcome these issues, we were the first in the world to use freeze-dried human induced pluripotent stem cell-derived megakaryocytes and platelets (S-FD-iMPs) and found that they have osteogenesis-promoting effects. Since turbulence was found to activate platelet biogenesis and iPS cell-derived platelets can now be produced on a clinical scale by a device called VerMES, this study examined the osteogenesis-promoting effect and safety of clinical-scale FD-iMP (V-FD-iMPs) for future human clinical application.
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- - Wearable trackers, like the JINS MEME eyeglasses, help monitor daily physical activity, which is essential for managing chronic diseases and enhancing overall health.
- - In a study with 42 healthy volunteers aged 20-60, the JINS MEME's data on physical activity showed a strong correlation (R=0.719, P<0.01) with participants' self-reported activity levels from the IPAQ questionnaire, particularly for walking.
- - The findings support the effectiveness of eyeglass-type wearable devices in accurately assessing physical activity and suggest their potential use in health monitoring and management strategies.
Co-administration of mirogabalin besylate and nonsteroidal anti-inflammatory drugs is effective for neuropathic pain; however, mechanism of its action remains unknown. We aimed to evaluate the mechanism of this synergistic effect of the concomitant administration for neuropathic pain using chronic constriction injury model rats. Fifty male Wister rats of 7-week-old were used.
View Article and Find Full Text PDF【PURPOSE】: Diffusion Tensor Imaging (DTI) with tractography is useful for the functional diagnosis of degenerative lumbar disorders. However, it is not widely used in clinical settings due to time and health care provider costs, as it is performed manually on hospital workstations. The purpose of this study is to construct a system that extracts the lumbar nerve and generates tractography automatically using deep learning semantic segmentation.
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- This study evaluates how integrating Retrieval Augmented Generation (RAG) with large language models (LLMs), like OpenAI's GPT-3.5, can improve the triage process in emergency medical care.
- Researchers created 100 simulated emergency scenarios to test the triage accuracy of RAG-enhanced LLMs against emergency medical technicians (EMTs) and physicians, finding the LLMs achieved a 70% correct triage rate compared to 35% and 50%, respectively.
- The results suggest that using RAG with LLMs can significantly reduce under-triage rates and improve the consistency of emergency medical assessments, indicating the need for further testing in real-life settings.
Introduction: The short T1 inversion recovery (STIR) sequence is advantageous for visualizing ligamentous injuries, but the STIR sequence may be missing in some cases. The purpose of this study was to generate synthetic STIR images from MRI T2-weighted images (T2WI) of patients with cervical spine trauma using a generative adversarial network (GAN). Methods: A total of 969 pairs of T2WI and STIR images were extracted from 79 patients with cervical spine trauma.
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- - The study investigated changes in gene expression related to DNA methylation in animal models of hip osteoarthritis (OA), focusing on peripheral blood mononuclear cells and synovial tissues.
- - After treatment with monoiodoacetate, animals showed clear signs of hip OA, including changes in pain sensitivity and increased expression of certain DNA methylation-related genes in the hip's synovial tissue.
- - The findings suggest that induced OA leads to significant alterations in global DNA methylation, potentially influencing disease progression and pain perception.
Article Synopsis
- The study evaluates a new imaging technique called MIXTURE, developed by Philips, which produces high-resolution T2 maps for diagnosing cervical radiculopathy.
- It compares T2 relaxation times and their variability using MIXTURE with another method, SHINKEI-Quant (S-Q), in both healthy participants and a patient with cervical disc herniation.
- Results show that MIXTURE provides significantly shorter T2 relaxation times and lower variability in measurements, indicating its potential for more accurate preoperative functional diagnosis of cervical nerve issues.
Objective: Vertebral artery (VA) injury poses a significant risk in cervical spine surgery, necessitating accurate preoperative assessment. This study aims to introduce and validate a novel approach that combines the Fast field echo that resembles a computed tomography using restricted echo spacing (FRACTURE) sequence with Time of Flight (TOF) Magnetic Resonance Angiography (MRA) for comprehensive evaluation of VA courses in the cervical spine.
Materials And Methods: A total of eight healthy volunteers and two patients participated in this study.
Article Synopsis
- This research examined the link between spinal characteristics and the length of the abdominal aorta in adult spinal deformity patients who had corrective surgery.
- Thirteen patients were studied, revealing that the abdominal aorta length increased post-surgery by an average of 4.8%.
- A negative correlation was found between changes in spinal alignment (specifically thoracolumbar kyphosis) and changes in aorta length, suggesting that spinal correction affects aorta elongation.
Article Synopsis
- Conventional methods for assessing vertebral rotation post-surgery are not comprehensive and this study focuses on using inverse trigonometric functions for analyzing adolescent idiopathic scoliosis (AIS) after posterior fusion surgery.
- The study analyzed data from 78 AIS patients, measuring rotation angles right after surgery and at two and five years later, finding a strong correlation between traditional CT measurements and calculated angles.
- The findings indicate the inverse trigonometric method effectively measures post-surgical rotation, with minimal changes over five years, while also identifying complications like the crankshaft phenomenon in a small percentage of patients.
Spinal fixation surgery has been increasingly performed in patients with osteoporosis. Romosozumab, a drug that was introduced in Japan recently, is known to possibly promote bone healing. However, few studies have reported the therapeutic effects of romosozumab in clinical practice in Japan.
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- The study aimed to compare patient outcomes using expandable versus static interbody spacers during oblique lateral interbody fusion (OLIF) surgery, utilizing CT and MRI imaging for evaluations.
- A total of 35 patients with degenerative disc disease were analyzed, measuring factors like cage height, lordosis, pain levels, and radiologic changes both preoperatively and 6 months post-op.
- Results indicated that expandable spacers provided better clinical outcomes, including less cage subsidence, improved dural sac area, better correction of vertebral slippage, and reduced leg numbness compared to static spacers.
Spinal injuries, including cervical and thoracolumbar fractures, continue to be a major public health concern. Recent advancements in machine learning and deep learning technologies offer exciting prospects for improving both diagnostic and prognostic approaches in spinal injury care. This narrative review systematically explores the practical utility of these computational methods, with a focus on their application in imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI), as well as in structured clinical data.
View Article and Find Full Text PDFStudy Design: Cross-sectional study.
Purpose: This cross-sectional study aimed to investigate the risk factors for osteoporosis in men by assessing bone mineral density (BMD), skeletal muscle mass, body fat mass, grip strength, and advanced glycation end products (AGEs).
Overview Of Literature: Fewer studies have reported the correlation between BMD and skeletal muscle mass in women.
Article Synopsis
- Pyogenic vertebral osteomyelitis (PVO) is a common infection among the elderly that can lead to serious complications like abscesses, often making traditional treatments ineffective.
- A case study focused on a 76-year-old man suffering from PVO and abscesses who didn't respond to antibiotics, undergoing a two-stage surgical procedure for treatment.
- The innovative use of retroperitoneal continuous local antibiotic perfusion (CLAP) during surgery showed significant success, greatly reducing pain and the size of abscesses, highlighting its potential as a new treatment option for resistant cases.
Introduction: This study aimed to determine whether the proximity of the median arcuate ligament (MAL) and the celiac artery (CA) changes in patients following surgery to correct adult spinal deformity (ASD). We hypothesized that the distance between the MAL and the CA shortens after corrective spinal surgery, which may cause acute celiac artery compression syndrome (ACACS).
Methods: A total of 89 patients (68.
Introduction: Low-back pain causes sleep disorders, which impairs the quality of life (QOL) of patients. Sleep disorders are associated with lumbar spinal stenosis (LSS); however, the postoperative effects of LSS surgery on sleep disorders are unknown. This study aimed to assess sleep disorders in patients with LSS using wearable activity trackers and determine whether surgery improves sleep quality.
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- Osteoporosis affects 18.3% of the global population and can lead to a 20% reduction in survival rates when paired with fragility fractures. In Japan, around 12.8 million people have osteoporosis, with approximately 193,400 hip fractures annually.
- The study analyzed data from 2018 to compare published mortality rates due to osteoporosis (191 deaths) with individual death certificates for those 80 and older, focusing on deaths from hip or spinal fractures resulting from falls.
- Results showed only 190 deaths attributed to osteoporosis in published data, while 3,437 elderly deaths due to hip or spinal fractures were found in death certificates, suggesting the actual mortality rate from osteoporosis may be around 3,627,