Publications by authors named "Kazufusa Takahashi"
Article Synopsis
- Basophils are rare immune cells that play vital roles in allergic reactions and defense against parasites, but how they activate and produce inflammation is not well understood, prompting research into RNA-binding proteins like tristetraprolin (TTP).
- Through various experiments, including RNA sequencing and mRNA stability assays on TTP-deficient mice, the study found that without TTP, basophils produce more inflammatory molecules and have prolonged mRNA stability for these mediators.
- The absence of TTP leads to increased allergic inflammation in a skin model, suggesting that targeting TTP could be a potential therapeutic approach for managing allergies.
Article Synopsis
- Monocytes and macrophages are diverse cell types, with traditionally understood pathways showing Ly6C classical monocytes turning into pro-inflammatory Ly6C macrophages.
- New research indicates that these classical monocytes can also differentiate into pro-resolving macrophages under specific conditions, particularly highlighted in allergic skin lesions.
- The study reveals a stepwise transformation from Ly6C classical monocytes to pro-resolving macrophages, essential for reducing inflammation and preventing issues like abscess formation when this process is impaired.
Phosphodiesterase 4 inhibitors have been approved for the treatment of atopic dermatitis. However, the cellular and molecular mechanisms underlying their therapeutic effect remain to be fully elucidated. In this study, we addressed this unsolved issue by analyzing the action of difamilast, a novel phosphodiesterase 4 inhibitor, on an oxazolone-induced skin allergic inflammation commonly used as a mouse model of atopic dermatitis.
View Article and Find Full Text PDFBackground: Patients with atopic dermatitis (AD) often show the infiltration of basophils in the affected skin. Because basophils represent only a minor fraction among cellular infiltrates in the skin lesion, the functional significance of skin-infiltrating basophils in AD pathogenesis remains ill-defined. In this study, we aimed to clarify the role of basophils and their effector molecules triggering skin inflammation in oxazolone (OX)-induced murine model of AD.
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