Publications by authors named "Kazufumi Ida"
Unlabelled: Inherited antithrombin deficiency is an autosomal dominant thrombophilia, resulting from genetic variations in the serpin family C member 1 (SERPINC1) gene. Antithrombin deficiency increases the risk of venous thromboembolism (VTE) compared to the general population. In this report, a novel missense variant of , c.
View Article and Find Full Text PDFBackground Differences in the clinical course of heritable thoracic aortic disease based on the disease-causing gene have not been fully evaluated. To clarify the clinical relevance of causative genes in heritable thoracic aortic disease, we assessed the clinical course of patients categorized based on genetic diagnosis. Methods and Results We investigated cardiovascular events and mortality in 518 genetically diagnosed patients in 4 groups: Group 1, (n=344); Group 2, , , , or (n=74); Group 3, (n=60); and Group 4, or (n=40).
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- - Heparin anticoagulant therapy during pregnancy poses bleeding risks, leading researchers to implement a less-intensive protocol using unfractionated heparin (UFH) with specific therapeutic targets for APTT ratio and antithrombin activity.
- - A study involving ten pregnant Japanese patients showed that seven patients (heparin-sensitive group) maintained therapeutic levels, while three patients (heparin-resistant group) struggled, largely due to conditions like antithrombin deficiency.
- - Despite the challenges in the HR group, there were no major bleeding incidents or thromboembolic episodes in either group, suggesting that this less-intensive anticoagulation approach can be effective, especially for those who respond well to heparin.