Publications by authors named "Kazue Horio"
Article Synopsis
- A 67-year-old Japanese woman with liver cirrhosis from primary biliary cholangitis was admitted to the hospital after losing consciousness.
- She was diagnosed with hepatic encephalopathy (HE) through imaging and symptoms assessment.
- Molecular tests showed a link between urease-positive S. salivarius found in her saliva and stool, suggesting it may contribute to increased ammonia production and subsequent HE in cirrhosis patients.
Introduction: Limited data are available on the correlation between microbial communities and metabolic dysfunction-associated fatty liver disease (MAFLD). This study aimed to evaluate the influence of MAFLD on diverse microbial communities.
Methods: We recruited 43 patients with a nonviral liver disease.
Aim: We performed genomic analysis to study the relative abundance of a urease-positive Streptococcus salivarius group isolated from the saliva of patients with chronic liver disease.
Methods: Male and female patients with chronic liver disease aged over 20 years were included. First, we assessed the frequency and type of the S.
Background: Lenvatinib is appropriate for reducing the production of nitric oxide (NO) and facilitating as block angiogenesis. However, to our knowledge, there are no data that support the correlation between NO and clinical response in patients who received lenvatinib therapy for HCC. Therefore, we investigated the correlation between the change rate of NO levels and clinical responses including adverse events (AEs) after lenvatinib therapy for unresectable hepatocellular carcinoma (HCC).
View Article and Find Full Text PDFPurpose: Promoter DNA methylation of various genes has been associated with metachronous gastric cancer (MGC). The cancer-specific methylation gene, , has been implicated in the occurrence of residual gastric cancer. We evaluated whether DNA methylation of could be a predictive biomarker of MGC using specimens of MGC developing on scars after endoscopic submucosal dissection (ESD).
View Article and Find Full Text PDFBackground: Data regarding the influence of patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism for patients with liver cirrhosis (LC) are scarce.
Objective: This study assesses the role of the PNPLA3 polymorphism for the development of LC and its complications by the findings of genetic examinations.
Methods: Patients with LC caused by virus (n = 157), alcohol (n = 104), nonalcoholic fatty liver disease (NAFLD) (n = 106), or autoimmune disease (n = 33) and without LC (n = 128) were enrolled.