Emotional valence sensing using a wearable facial EMG device.

Emotion sensing using physiological signals in real-life situations can be practically valuable. Previous studies have developed wearable devices that record autonomic nervous system activity, which reflects emotional arousal. However, no study determined whether emotional valence can be assessed using wearable devices.

(S)-stereoisomer of telomestatin as a potent G-quadruplex binder and telomerase inhibitor.

Total synthesis of the (S)-stereoisomer of telomestatin (1) was accomplished. (S)-Telomestatin exhibited potency four times that of the natural product, (R)-telomestatin, which was the most potent telomerase inhibitor previously reported. In the circular dichroism spectral analysis of the complexes possessing randomly structured single-stranded d[TTAGGG](4) oligonucleotide, (S)-telomestatin, like (R)-telomestatin, induced an antiparallel G-quadruplex structure.

Estimation of cancer incidences in Aichi prefecture: use of a model area with good quality registry data.

In Japan, local government is responsible for organization of population-based cancer registries and the quality of the registration remains modest, mainly due to dependence on voluntary-based operations without legal obligations. Aichi Prefecture cancer registry covers a large population, estimated at 7 million, and its quality has yet to reach the level required internationally. The derived cancer incidences for Aichi Prefecture therefore tend to be underestimated.