Publications by authors named "Kazimirsky A"

The review describes the influence of serotonin (5-HT) and its receptor, transporter SERT and nuclear factor Nf-kB on the immune function of the body, particularly in the digestive tract. The mechanisms of the synthesis, metabolism and catab. olism of 5-HT are characterized.

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In this work, using molecular dynamics simulation, we study conformational and dynamic properties of biologically active penta- and tetrapeptides derived from fetoplacental proteins such as alpha-fetoprotein, pregnancy specific β1-glycoprotein, and carcinoembryonic antigen. Existence of correlation between flexibility of peptide backbone and biological activity of the investigated peptides was shown. It was also demonstrated that flexibility of peptide backbone depends not only on its length, but also on the presence of reactive functional groups in amino acid side chains that participate in intramolecular interactions.

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Conformational dynamics of a biologically active fragment of alpha-fetoprotein, the heptapeptide LDSYQCT, and its analogs obtained by site-directed substitutions of amino acid residues were studied. The conformational dynamics of the peptide were conservative under the substitutions Y17F, Y17S, and D15E. Substitutions C19A and S16V resulted only in local changes in the dynamic behavior of the peptide.

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It was demonstrated that all vitiligo patients, independently of the disease stage, have a significant decrease in the total number of T cells and an elevated level of peripheral blood lymphocytes and activated natural killers (CD56). The low level of T lymphocytes is associated with the increase in the number of CD3(+)4(+)8(+) cells, which are characterized by a faster apoptosis induction. The elevated level of B lymphocytes in peripheral blood in vitiligo is due to the significant increase in the number of B cells of all the stages of differentiation, suggesting a general activation of the whole B-cell immunity.

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Human alpha-fetoprotein (AFP) is capable of modulating cellular proliferative processes. A study has been made of the regulatory properties of a synthetic peptide corresponding to the part of the human AFP molecule participating in receptor interaction, the peptide consisting of seven amino acids and having an amino acid sequence LDSYQCT. The study was carried out on the lymphocytes of the peripheral blood of six patients with immune myocarditis in the period of exacerbation of the illness.

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A study of the expression of activated markers in peripheral blood lymphocytes makes it possible to carry out continuous monitoring of the immune system of a patient by means of a non-invasive method. This is of great importance for patients with acute myocarditis with immunopathological processes. However, there are very few papers in medical literature which are dedicated to this problem.

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We have conducted a comparative study of the lymphocyte surface antigens in patients with atopic bronchial asthma (ABA) in an acute stage and during clinical remission of the disease using a wide variety of monoclonal antibodies. In patients with ABA, independently of the stage of the disease, we have observed a decline in the total number of T lymphocytes due to cell reduction in both sub-populations--T helpers and cytotoxic T cells. During the acute phase of the disease a significant increase in the number of B lymphocytes at all stages of differentiation was observed.

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