Publications by authors named "Kazi S Islam"
Article Synopsis
- - Background: NAPQI, a toxic byproduct of paracetamol, can accumulate in the liver, leading to damage by depleting glutathione and disrupting mitochondrial function, which increases superoxide production and decreases ATP levels.
- - Methods: Researchers used techniques like molecular docking and simulations, along with protein interaction analysis, to explore how NAPQI binds to succinate dehydrogenase (SDH), a mitochondrial enzyme, under realistic cellular conditions by including a lipid membrane.
- - Results: The study found that both paracetamol and NAPQI have strong binding affinities for SDH, with NAPQI showing slightly more stability, helping to predict the mechanisms behind paracetamol's liver toxicity and identify
Article Synopsis
- - High-latitude ecosystems are warming more quickly than other areas, affecting plants like the Ericaceous shrub Empetrum nigrum, which may benefit from this warming due to its interaction with root-associated fungi.
- - In experiments, researchers found that warming reduced the carbon (C) allocated to fungi when the shrub used a simple form of nitrogen (N) but increased C allocation with a more complex N form, indicating a change in nutrient exchange dynamics.
- - The study highlights the need to consider different forms of nitrogen sources when studying plant-fungi interactions under warming conditions, suggesting that simpler nitrogen sources may not accurately reflect the complexities of these relationships.
Inside the bone marrow, plasma cells are created, and they are a type of white blood cells. They are made from B lymphocytes. Antigens are produced by plasma cells to combat bacteria and viruses and prevent inflammation and illness.
View Article and Find Full Text PDF• Cardiac myxoma can present with prolonged fever and pleural effusion. • Multichamber myxoma should raise the suspicion of Carney complex. • Echocardiography plays a pivotal role for diagnosis, treatment planning, and follow-up.
View Article and Find Full Text PDFThe calcium-sensing receptor (CaSR) is critical for skeletal development, but its mechanism of action in osteoblasts is not well-characterized. In the central nervous system (CNS), Homer scaffolding proteins form signaling complexes with two CaSR-related members of the G protein-coupled receptor (GPCR) family C, metabotropic glutamate receptor 1 (mGluR1) and mGluR5. Here, we show that CaSR and Homer1 are co-expressed in mineralized mouse bone and also co-localize in primary human osteoblasts.
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