Publications by authors named "Kazi Asraful Alam"
Article Synopsis
- The study investigates the relationship between insulin resistance (IR)-related conditions, like type 2 diabetes and obesity, and neuropsychiatric disorders, highlighting the complexity of their co-occurrence as a public health issue.
- Researchers used genome-wide association studies (GWASs) with a large sample size to analyze genetic correlations between these conditions, identifying various genomic regions with significant local correlations.
- The findings suggest that these correlated regions are linked to important biological pathways, indicating potential targets for treatments and a need for an integrated approach to understanding and managing these interconnected health problems.
Potassium channels (K-channels) selectively control the passive flow of potassium ions across biological membranes and thereby also regulate membrane excitability. Genetic variants affecting many of the human K-channels are well known causes of Mendelian disorders within cardiology, neurology, and endocrinology. K-channels are also primary targets of many natural toxins from poisonous organisms and drugs used within cardiology and metabolism.
View Article and Find Full Text PDFThe acknowledged potential of small-molecule therapeutics targeting disease-related protein-protein interactions (PPIs) has promoted active research in this field. The strategy of using small molecule inhibitors (SMIs) to fight strong (tight-binding) PPIs tends to fall short due to the flat and wide interfaces of PPIs. Here we propose a biligand approach for disruption of strong PPIs.
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