Publications by authors named "Kazeo Ninomiya"
Article Synopsis
- A multicenter study in Japan was conducted to evaluate adverse events (AEs) related to the tag-less PillCam patency capsule (PC) used to prevent small bowel capsule endoscope (CE) retention.
- Out of 2578 patients, 74 AEs were identified, primarily involving residual parylene coating, small bowel obstruction, and CE retention, with a 2.37% incidence rate of AEs overall.
- The study concluded that while the PC is generally safe, careful assessment of patient history and accurate localization of the capsule are important to mitigate risks.
Background/aims: Decreased trough levels of infliximab (TLI) and antibodies to infliximab (ATI) are associated with loss of response (LOR) in Crohn's disease. Two prospective studies were conducted to determine whether TLI or ATI better correlates with LOR (Study 1), and whether TLI could become a predictor of mucosal healing (MH) (Study 2).
Methods: Study 1 was conducted in 108 patients, including those with LOR and remission to compare ATI and TLI in discriminating the 2 conditions based on receiver operating characteristic (ROC) curve analyses.
Background: Capsule endoscopy (CE) has allowed the characterization of small bowel lesions. However, small bowel lesions in ulcerative colitis (UC) have not been elucidated and no studies have compared between UC and Crohn's disease (CD).
Aim: The objective of this study was to investigate the small bowel lesions in UC, and to characterize UC lesions by comparison with CD.
Article Synopsis
- This study analyzed the incidence of intestinal complications like stenosis and fistulas in patients with Crohn's disease (CD) at a Japanese hospital, finding that about 50% develop these issues within 5 years.
- The research involved 520 patients and looked at the cumulative rates of initial surgeries, revealing that about 50% of patients required surgery after 10 years.
- Identified risk factors for undergoing initial surgery included being a current smoker and having moderate to severe stenosis in various parts of the intestines, particularly in those with upper gastrointestinal disease at diagnosis.
Background: Fujifilm developed blue laser imaging (BLI) via a laser light source with a narrow-band light observation function. It has a brighter BLI bright mode for tumor detection.
Objective: To investigate whether the BLI bright mode can improve the visibility of colorectal polyps compared with white light (WL).
Background And Aim: The aim of the present study was to endoscopically evaluate ileal mucosal healing during maintenance therapy with infliximab in order to investigate the clinical significance of endoscopic examination of ileal lesions in Crohn's disease patients.
Methods: This study retrospectively analyzed 54 patients who mainly had active ulcers of the ileum on endoscopy at baseline who were responsive to infliximab induction and who received infliximab maintenance therapy. Mucosal healing was defined as no ulcer or only ulcer scar.
Background And Aim: Endoscopic balloon dilation (EBD) is an alternative to surgery for small bowel strictures of patients with Crohn's disease (CD). However, little is known about the long-term efficacy of EBD. The aim of the present study was to clarify the long-term outcome of EBD for small bowel strictures in patients with CD.
View Article and Find Full Text PDFBackground: Magnifying endoscopy (ME) with narrow-band imaging (NBI) has been described as useful in diagnosing colorectal neoplasms. However, there is no standardized simple classification system, and its usefulness in comparison with pit pattern diagnosis by magnifying chromoendoscopy (MC) is unclear. The aim of this study was to investigate the usefulness of evaluations of microvascular architecture (MV) and microsurface structure (MS) by ME with NBI in the diagnosis of colorectal neoplasms.
View Article and Find Full Text PDFBackground And Aim: Capsule endoscopy (CE) is effective in the detection of small bowel lesions. Many studies have been conducted on the effectiveness of preparations in improving diagnostic yield, but an effective method has yet to be confirmed. We used magnesium citrate as preparation for CE and evaluated its effectiveness.
View Article and Find Full Text PDFBackground: Although rare, duodenal lesions have been reported in association with ulcerative colitis (UC); however, there have been very few reports on small bowel lesions, and many aspects of their pathology and frequency remain unknown. This study determined whether small bowel lesions are present in UC by using wireless capsule endoscopy (WCE).
Patients And Methods: WCE was performed on 20 patients with active UC and 10 who had undergone proctocolectomy.
Aim: Recent reports have focused on the development of secondary amyloidosis (AMY) as a complication of Crohn's disease (CD). The present study was carried out to investigate the frequency of AMY secondary to CD, its clinical and endoscopic features, and the importance of duodenal biopsy in detecting this disease.
Methods: This study involved 408 patients diagnosed with CD who were endoscopically and histologically examined at our hospital.
Background And Aim: Ulcerative colitis (UC) is not only characterized by pathological lesions localized to colonic mucosa, but also to various complications involving other organs, including postoperative pouchitis. Among these complications, diffuse gastroduodenitis with lesions resembling colonic lesions has been reported, albeit rarely.The aim of the present study was to attempt to characterize the lesions of the upper gastrointestinal tract occurring as a complication of UC, and to assess the frequency and clinical course of these lesions.
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