Pharmacological properties of a potent neuroleptic drug octoclothepin.

Octoclothepin, 8-chloro-1-(4-methylpiperazino)-10,11-dihydrodibenzo (b,f) thiepin, is a very potent neuroleptic drug with pronounced central antidopaminergic and antiserotonin actions. In most animal experiments, its plharmacological profile resembles that of perphenazine. Octoclothepin reveals an intensive central depressant action in a series of observational and instrumental procedures in rodents.

[Pharmacologic effect of protracted neuroleptics, fluphenazine oenanthate and oxyprothepine oenanthate (VUFB 9447)].

Two neuroleptica with protracted effect, i.e. Fluphenazin-Oenanthat and Oxyprothepin-Oenanthat, were tested on rats, dogs and rabbits.