Publications by authors named "Kazama K"
Background/aim: The aim of the present study was to evaluate the clinical impact of the Global Immune-Nutrition-Information Index (GINI) in patients with esophageal cancer (EC) who received curative treatment and to clarify the potential of the GINI as a prognostic factor.
Patients And Methods: Patients who underwent curative resection for EC at Yokohama City University between 2000 and 2020 were consecutively chosen based on their medical records. The GINI was defined as follows: GINI=[C-reactive protein×platelet×monocyte×neutrophil]/[albumin×lymphocyte].
Article Synopsis
- This study examined how anemia affects short- and long-term outcomes in patients with resectable gastric cancer undergoing curative treatment.
- A total of 330 patients were reviewed, revealing that those with preoperative hemoglobin levels below 11 g/dl had significantly lower survival rates compared to those with higher levels.
- The findings suggest that addressing perioperative anemia could improve the overall survival and reduce complications for gastric cancer patients receiving treatment.
A 58-year-old man was treated with radical excision for rectal cancer. Pathological findings were pT3N1M0, Stage ⅢB, RAS: mutant, BRAF: mutant, MSS. The patient was followed up without adjuvant chemotherapy.
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- Four years later, a CT scan showed a suspicious enlarged lymph node, leading to a diagnosis of recurrent cancer and subsequent laparoscopic surgery.
- After surgery, the patient received adjuvant chemotherapy (CAPOX) and has remained cancer-free for over 2.5 years, highlighting the importance of close follow-up due to a 6.3% recurrence rate in similar cases.
A case of esophageal cancer in a diverticulum treated by surgical resection: a case report.
Gen Thorac Cardiovasc Surg Cases
November 2023
Background: An esophageal diverticulum is a relatively rare disease, with reports of treatment for esophageal cancer in the diverticulum even rarer.
Case Presentation: The case involved a 72-year-old male with a chief complaint of dysphagia. He was diagnosed with an esophageal diverticulum (Zenker's diverticulum) measuring 10 cm in diameter.
deficiency in male mice led to abnormal sperm morphology and reduced sperm motility.
Front Cell Dev Biol
October 2024
Article Synopsis
- Infertility impacts over 15% of people globally, with genetic mutations being a significant factor in its occurrence.
- This study utilized a CRISPR-Cas9 knockout mouse model to investigate the role of the TLE6 protein in male fertility, finding that knockout males had lower sperm counts and impaired sperm maturation.
- Results indicated that TLE6 is essential for proper sperm function and production, with mutations potentially contributing to human infertility issues.
Background/aim: We hypothesized that the inflammatory burden index (IBI) is a promising biomarker for esophageal cancer (EC) treatment and management. To confirm our hypothesis, we evaluated the prognostic impact of IBI in patients with EC who received curative treatment.
Patients And Methods: We conducted a retrospective review of medical records and collected data from consecutive patients with EC who underwent curative resection at Yokohama City University between 2005 and 2020.
Article Synopsis
- The study investigates the systemic immune-inflammation index (SII) as a predictor of prognosis in patients with esophageal cancer who had curative surgery.
- Researchers analyzed data from 180 patients, classifying them into SII-high and SII-low groups based on a cutoff value of 500, finding significant differences in overall survival (OS) and recurrence-free survival (RFS) rates between the two groups.
- Results showed that a higher SII correlated with poorer survival outcomes and a greater chance of hematological recurrence, indicating that the SII could be a valuable marker for managing esophageal cancer.
Objective: To investigate the incidence of male sexual dysfunction (SD) including erectile dysfunction (ErD) and ejaculatory dysfunction (EjD) after minimally invasive rectal cancer surgery.
Background: Male SD significantly affects post-rectal cancer surgery quality of life (QOL). Current assessments using the International Index of Erectile Function-5 are unsuitable for patients with reduced postoperative sexual activity, because it assumes sexual intercourse.
Objective: To investigate radiographic detection by excretory urography of morphological changes in the urinary bladder associated with urachal anomalies in calves.
Methods: Excretory urography was performed to detect morphological changes in the urinary bladder of 13 calves, of which 6 were nondysuric with swelling of umbilical region and 7 were dysuric without clinical umbilical swelling from November 2022 through April 2024.
Results: The urinary bladder was delineated in all 13 calves after excretory urography.
Article Synopsis
- * Out of 159 patients evaluated, over half experienced loss of skeletal muscle mass during neoadjuvant chemotherapy, which correlated with a significantly lower completion rate of S-1 adjuvant chemotherapy.
- * The findings suggest that addressing skeletal muscle loss during neoadjuvant chemotherapy could enhance the continuation of adjuvant treatment and potentially improve survival rates in these patients.
Aim: Intracorporeal anastomosis (IA) is becoming increasingly popular and replacing extracorporeal anastomosis (EA) for reconstruction in laparoscopic and robotic surgery for right-sided colon cancer (LSRCC). Intracorporeal overlap anastomosis (IOA) is the most widely used IA technique. This study aimed to examine the safety of IOA by investigating its short-term results during the implementation phase.
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- A 31-year-old woman experienced a sudden headache and altered consciousness, leading to the discovery of a left acute subdural hematoma and a small aneurysm on her left distal posterior cerebral artery, which was treated with coil embolization.
- Two weeks later, she developed complete left hemiplegia due to an occluded right middle cerebral artery, requiring a mechanical thrombectomy that successfully restored blood flow.
- Ultimately, she was diagnosed with infective endocarditis after positive blood cultures revealed bacterial presence and a TEE identified vegetation on the mitral valve; she was treated with penicillin and discharged without neurological deficits.
Background/aim: We hypothesized that the hemoglobin, albumin, lymphocyte, and platelet (HALP) score may be a promising marker for the treatment and management of gastric cancer (GC). To test this hypothesis, we evaluated the clinical impact of the HALP score in patients with GC who received curative treatment.
Patients And Methods: Consecutive patients who underwent curative resection for GC at the Yokohama City University between 2005 and 2020 were selected based on their medical records.
Background: Although functional end-to-end anastomosis (FEEA) using a stapler in the colorectal field has been recognised worldwide, the technique varies by surgeon, and the safety of anastomosis using different techniques is unknown.
Methods: This multicentre prospective observational cohort study was conducted by the KYCC Study Group in Yokohama, Japan, and included patients who underwent colonic resection at seven centres between April 2020 and March 2022. This study compared the incidence of surgery-related abdominal complications (SAC: anastomotic leakage [AL], anastomotic bleeding, intra-abdominal abscess, enteritis, ileus, surgical site infection, and other abdominal complications) between two different methods of FEEA (one-step [OS] method: simultaneous anastomosis and bowel resection; two-step [TS] method: anastomosis after bowel resection).
Background/aim: Systemic immune-inflammation index (SII) was developed and evaluated for various malignancies. This study evaluated the clinical impact of the SII in patients with gastric cancer (GC) who received curative treatment.
Patients And Methods: Patients who underwent curative resection for GC at Yokohama City University between 2005 and 2020 were chosen consecutively based on their medical records.
Purpose: Although there have been many reports on learning curves for robotic surgery, it is unclear how surgeons' conventional laparoscopic surgical skills influence their ability in performing robotic surgery for colorectal cancer (CRC). The aim of this study was to determine the surgical outcomes of robotic surgery for CRC during the induction phase by skilled laparoscopic surgeons.
Methods: Surgical outcomes of consecutive CRC cases between January 2021 and March 2023 following the skilled phase of laparoscopic surgery and introductory phase of robotic surgery performed by three skilled laparoscopic surgeons were compared.
Introduction: Indocyanine green fluorescence imaging (ICG-FI) reduces anastomotic leakage (AL) in rectal cancer surgery. However, no studies investigating risk factors for anastomotic leakage specific to the group using ICG-FI have ever previously been conducted. The purpose of this retrospective multicenter study was to ascertain the risk factors for AL in the group using ICG-FI.
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- * Researchers collected nasal swabs from 66 cattle, finding BRBV in 6 symptomatic and 4 asymptomatic animals, and sequenced nearly complete genomes of two Japanese BRBV strains.
- * The study revealed significant genetic differences in the BRBV leader gene in Japan compared to global strains, highlighting the virus's evolution and genetic diversity influenced by local factors.
Purpose: There have been no adequate comparisons of the efficacy, safety, and efficiency of analgesia after laparoscopic colorectal resection (LAC), with and without epidural anesthesia (EDA).
Methods: This was a multicenter prospective observational study of patients undergoing LAC. The primary end point was the mean visual analog scale (VAS) score on postoperative days (PODs) 1-7.
Background/aim: The albumin to fibrinogen ratio (AFR) has been identified as a promising prognostic marker for some malignancies. The aim of the present study was to evaluate the clinical impact of AFR in esophageal cancer patients who received curative resection.
Patients And Methods: The present study included 123 patients who underwent curative treatment for esophageal cancer between 2005 and 2020.
Article Synopsis
- - The study aims to evaluate the prognostic immune and nutritional index (PINI) as a marker for esophageal cancer patients who received curative treatment, based on data collected from patients at Yokohama City University from 2005 to 2020.
- - Analysis of 180 patients shows that those with a low PINI (≤3.0) had significantly poorer survival rates compared to those with a high PINI, making it a strong independent prognostic factor for overall and recurrence-free survival.
- - The findings suggest that PINI may serve as a valuable nutritional and inflammatory marker, potentially guiding treatment and management strategies for esophageal cancer patients.
Background/aim: The CRP-albumin-lymphocyte (CALLY) index is a promising biomarker. We clarified the clinical impact of the CALLY index in gastric cancer patients who received curative treatment.
Patients And Methods: Consecutive patients who underwent curative resection for gastric cancer at Yokohama City University from 2005 to 2020 were selected based on medical records.