Publications by authors named "Kazachenko E"

Article Synopsis
  • Haemorrhoidectomy often leads to significant postoperative pain and a decline in quality of life for patients; this study aimed to assess the effectiveness of an intraoperative perineal block as pain management for these surgeries.
  • In a controlled trial with 100 patients, those receiving the perineal block reported significantly less pain intensity, utilized fewer opioids, and enjoyed longer pain-free periods compared to those who only had spinal anaesthesia.
  • The findings suggest that the perineal block is a safe and effective technique that can enhance postoperative recovery and overall patient satisfaction after anorectal surgery.
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Background: Hemorrhoidectomy is associated with intense postoperative pain that requires multimodal analgesia. It includes nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and local anesthetics to reach adequate pain control. There are data in literature preemptive analgesia could decrease postoperative pain after hemorrhoidectomy.

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Hemorrhoidal disease is the most common proctologic disease and the search for new treatment methods, as well as an in-depth understanding of the mechanisms underlying effects of well-known agents on disease pathogenesis still remain relevant. There have been long recognized the effects of the bacterial culture suspension (BCS) as a therapeutic means eliciting decreased exudation during inflammation, wound healing, tissue regeneration, and stimulated immunity. Here, based on recent findings related to innate and adaptive immune cells, we set out to present mechanisms accounting for some effects coupled to commensal bacteria, particularly inactivated BCS, which are important for understanding pathogenesis-related action of drug Posterisan and Posterisan forte, and outline their broad application in therapy of hemorrhoids.

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