Publications by authors named "Kayuri Kuroda"
Ghrelin, a peptide hormone produced in the stomach, has been known to be involved in the regulation of gastric contraction in humans and rodents. To elucidate the detailed mechanisms of ghrelin on gastric contractions, we used Suncus murinus, a recently established small animal model for gastrointestinal motility. S.
View Article and Find Full Text PDFBackground: Gastric acidification inhibits motilin-induced gastric phase III contractions. However, the underlying mechanism has not been thoroughly investigated. Here, we studied the inhibitory mechanism by gastric acidification on motilin-induced contraction in Suncus murinus (S.
View Article and Find Full Text PDFMotilin was discovered in the 1970s as the most important hormone for stimulating strong gastric contractions; however, the mechanisms by which motilin causes gastric contraction are not clearly understood. Here, we determined the coordinated action of motilin and ghrelin on gastric motility during fasted and postprandial contractions by using house musk shrew (Suncus murinus; order: Insectivora, suncus named as the laboratory strain). Motilin-induced gastric contractions at phases I and II of the migrating motor complex were inhibited by pretreatment with (D-Lys(3))-GHRP-6 (6 mg/kg/h), a ghrelin receptor antagonist.
View Article and Find Full Text PDFArticle Synopsis
- The migrating motor complex (MMC) is a cyclic motor pattern seen in the upper GI tract during fasting, which is replaced by postprandial contractions after eating.
- Ghrelin and motilin both play a role in regulating the MMC, but the vagus nerve is crucial for gastric motility and initiates postprandial contractions.
- In experiments with conscious suncus, ghrelin enhanced phase II of the MMC only in animals with an intact vagus nerve, while motilin's ability to induce contractions was affected by vagotomy, highlighting the importance of the vagus nerve in these processes.