Publications by authors named "Kayu Yuan"
Article Synopsis
- IgG autoantibodies to heat shock protein 70 (HSP70) are linked to poor outcomes in patients with idiopathic pulmonary fibrosis (IPF), a lung disease associated with abnormal accumulation of fibroblasts.
- The study found that anti-HSP70 from IPF patients enhanced the expression of Bcl-2, a protein that inhibits apoptosis in lung fibroblasts, making them more resistant to cell death.
- This research highlights a new way autoimmunity affects fibroblast behavior by altering the epigenetic regulation of apoptosis, suggesting potential therapeutic targets for IPF and possibly other related diseases.
