Estradiol and tamoxifen reverse ovariectomy-induced physical inactivity in mice.

Unlabelled: Decreased physical activity and increased body mass are associated with estrogen deficiency.

Purpose: To determine whether estrogen or the estrogen analog, tamoxifen, could reverse those detrimental effects after surgical ovariectomy in mice.

Methods: Ten-week-old C57BL/6 mice were sham operated (sham, N = 6) or ovariectomized (OVX, N = 9).