Publications by authors named "Kayoko Ichimura"
Eosinophilic gastrointestinal disorders (EGIDs) are treated with corticosteroids and food allergen elimination. However, treatment for refractory cases is not standardized. We demonstrate the efficacy of vedolizumab, an anti-α4β7 integrin agent, in 2 children with duodenal ulcers developed by non-eosinophilic esophagitis EGIDs.
View Article and Find Full Text PDFThyroid involvement is rare in pediatric Langerhans cell histiocytosis (LCH). It may cause airway narrowing, leading to acute-onset respiratory distress. Severe cases may require emergent surgical interventions such as thyroidectomy, which should be avoided in children due to higher rates of complication, particularly in infancy.
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- Clinical autopsies help determine the disease processes leading to a patient's death and confirm diagnoses, especially in pediatric cases where the feedback can significantly impact families.
- The study focused on assessing the DNA quality in formalin-fixed, paraffin-embedded (FFPE) tissues from pediatric autopsies, finding that high-quality DNA can be extracted from various organ types shortly after fixation.
- Recommendations were made for an optimal process involving specific fixation and tissue sectioning methods to improve DNA preservation for future genomic analysis.
Liver cirrhosis due to secondary sclerosing cholangitis caused by Langerhans cell histiocytosis (LCH) has a poor prognosis, and liver transplantation is the definitive treatment. However, the optimal timing has not been established. We report a 2-year-old girl with LCH-related liver cirrhosis who successfully underwent liver transplantation before progressing to severe liver dysfunction.
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