Polyethylene glycol hypersensitivity, patient outcomes in a 7-year retrospective study.

Background: Immediate IgE-mediated hypersensitivity reactions to polyethylene glycol (PEG) are rare. Our understanding of PEG hypersensitivity is limited.

Objective: To evaluate the clinical characteristics and investigation outcomes of the largest cohort of patients with PEG allergy reported.

Establishment of Twinning Partnership to Improve Pediatric Radiotherapy Outcomes Globally.

Purpose: Pediatric radiotherapy is a necessary and challenging component of oncologic care for children in low- and middle-income countries (LMICs). Collaboration between institutions in LMICs and high-income countries (HICs) has been shown to be effective in improving oncologic treatment outcomes; however, literature regarding pediatric radiotherapy twinning partnerships is limited.

Methods: Emory University has a long-standing twinning collaboration with Tikur Anbessa Specialized Hospital (TASH) for certain medical specialties.

Implementation of a Novel Chart Rounds Application to Facilitate Peer Review in a Virtual Academic Environment.

Purpose: Peer review in the form of chart rounds is a critical component of quality assurance and safety in radiation therapy treatments. Radiation therapy departments have undergone significant changes that impose challenges to meaningful review, including institutional growth and increasing use of virtual environment. We discuss the implementation of a novel chart rounds (NCR) format and application adapted to modern peer review needs at a single high-volume multisite National Cancer Institute designated cancer center.

Vitamin B Hypersensitivity: A Retrospective Multicenter Study.

Background: Vitamin B (Vit B) deficiency affects approximately 20% of those above the age of 60 years in the United Kingdom and United States. If untreated, it leads to detrimental health outcomes.

Objective: To investigate a cohort of patients with Vit B hypersensitivity (VB12H) referred to 3 UK allergy centers and design a pathway for the investigation of VB12H.

Antioxidant and antilipidemic action of ketogenic diet and tomato powder mix in high sugar and fat fed Harwich fruit flies.

Numerous studies have demonstrated the role of oxidative stress in metabolic disorders which presents as a major global problem. The antioxidant properties of the tomato fruit and the ketogenic diet has likewise been established by different authors. This study uses a fruit fly model to examine the synergistic effect of a ketogenic diet and tomato powder mix on biochemical alterations induced by the High-Fat Diet (HFD) and the High-Sugar Diet (HSD).

The interplay between monosodium glutamate (MSG) consumption and metabolic disorders.

Monosodium glutamate (MSG) is one of the most popular food additives in the world and is often ingested with commercially processed foods. It can be described as a sodium salt of glutamic acid with the IUPAC name - Sodium 2-aminopentanedioate and is ionized by water to produce free sodium ions and glutamic acid. MSG use has significantly increased over the past 30 years, its global demand stands huge at over three million metric tons which is worth over $4.

Factors affecting exclusive breastfeeding practices among working-class women in Osun State, Nigeria.

Breastfeeding has been accepted as the most vital intervention for reducing infant mortality and ensuring optimal growth and development of children. However, studies on the factors affecting exclusive breastfeeding, especially, among working-class women are sparse. This study determined the factors affecting exclusive breastfeeding among working-class women in Osun state.

Evaluating Pareto optimal tradeoffs for hippocampal avoidance whole brain radiotherapy with knowledge-based multicriteria optimization.

The goal of this study is to investigate the Pareto optimal tradeoffs between target coverage and hippocampal sparing using knowledge-based multicriteria optimization (MCO). Ten prior clinical cases were selected that were treated with hippocampal avoidance whole brain radiotherapy (HA-WBRT) using VMAT. A new, balanced plan was generated for each case using an in-house RapidPlan model in the Eclipse V16.

Repair of a Perforated Marginal Ulcer Seven Years After Roux-en Y Gastric Bypass: A Case Report and Review of Literature.

Marginal ulcers can be a rare but fatal post-surgical complication of Roux-en-Y gastric bypass (RYGB). In this report, we will describe the case of a 70-year-old female, with a seven-year status post-gastrojejunostomy who presented with a perforated marginal ulcer and showed significant improvement in her symptoms after a revisional operation for the marginal ulcer. The goal of this case report is to make clinicians aware of the unique complications of RYGB and outline the appropriate workup for patients presenting with post-bariatric abdominal pain.

Sphingosine-1-phosphate induces airway smooth muscle hyperresponsiveness and proliferation.

Background: The emerging role of sphingosine-1-phosphate (S1P) in regulating smooth muscle functions has led to the exploration of the possibility that this sphingolipid could represent a potential therapeutic target in asthma and other lung diseases. Several studies in animal surrogates have suggested a role for S1P-mediated signaling in the regulation of airway smooth muscle (ASM) contraction, airway hyperresponsiveness, and airway remodeling, but evidence from human studies is lacking.

Objective: We sought to compare the responsiveness of the airways to S1P in healthy and asthmatic individuals in vivo, in isolated human airways ex vivo, and in murine airways dissected from healthy and house dust mite (HDM)-sensitized animals.

Nonlinear inversion of electrical resistivity sounding data for multi-layered 1-D earth model using global particle swarm optimization (GPSO).

Interpreting geophysical data requires solving nonlinear optimization problem(s) in inversion. Analytical methods such as least-square have some intrinsic limitations, which include slow convergence and dimensionality, making heuristic-based swarm intelligence a better alternative. Large-scale nonlinear optimization problems in inversion can be solved effectively using a technique within the swarm intelligence family called Particle Swarm Optimization (PSO).

Factors Associated with Atopic Dermatitis among Children Aged 6 to 14 Years in Alimosho Local Government, Lagos, Nigeria.

There has been a rise in the prevalence of atopic dermatitis (AD) globally, especially in low-and middle-income countries such as Nigeria. The condition has been linked to genetic predisposes, living conditions, and environmental factors. Environmental factors are considered a significant contributor to AD in low- and middle-income countries.

Impact of COVID-19 pandemic on mother and child health in Sub-Saharan Africa - a review.

Prior to the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, there was a decrease in the maternal mortality rate in Sub-Saharan Africa (SSA) by 38%. This corresponds to a decline of 2.9% on average each year.

H, N, C backbone and Cβ resonance assignments for UBQLN1 UBA and UBAA domains.

UBQLN1 functions in autophagy and proteasome-mediated protein degradation. It contains an N-terminal ubiquitin-like domain (UBL), a C-terminal ubiquitin-associated domain (UBA), and a flexible central region which functions as a chaperone to prevent protein aggregation. Here, we report the H, N, and C resonance assignments for the backbone (H, N, C', Cα, and Hα) and sidechain Cβ atoms of the UBQLN1 UBA and an N-terminally adjacent segment called the UBA-adjacent domain (UBAA).

E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure.

The E3 ligase E6AP/UBE3A has a dedicated binding site in the 26S proteasome provided by the RAZUL domain of substrate receptor hRpn10/S5a/PSMD4. Guided by RAZUL sequence similarity, we test and demonstrate here that the E6AP AZUL binds transiently to the UBA of proteasomal shuttle factor UBQLN1/2. Despite a weak binding affinity, E6AP AZUL is recruited to UBQLN2 biomolecular condensates in vitro and E6AP interacts with UBQLN1/2 in cellulo.

Lung SBRT treatment planning: a study of VMAT arc selection guided by collision check software.

To evaluate the effects of arc geometry on lung stereotactic body radiation therapy (SBRT) plan quality, using collision check software to select safe beam angles. Thirty lung SBRT cases were replanned 10Gy x 5 using 4 volumetric modulated arc therapy (VMAT) geometries: coplanar lateral (cpLAT), coplanar oblique (cpOBL), noncoplanar lateral (ncpLAT) and noncoplanar oblique (ncpOBL). Lateral arcs spanned 180° on the affected side whereas the 180° oblique arcs crossed midline to spare healthy tissues.

Assessment of Clinical Information Quality in Digital Health Technologies: International eDelphi Study.

Background: Digital health technologies (DHTs), such as electronic health records and prescribing systems, are transforming health care delivery around the world. The quality of information in DHTs is key to the quality and safety of care. We developed a novel clinical information quality (CLIQ) framework to assess the quality of clinical information in DHTs.

Evaluating the plan quality of a general head-and-neck knowledge-based planning model versus separate unilateral/bilateral models.

The implementation of knowledge-based planning (KBP) continues to grow in radiotherapy clinics. KBP guides radiation treatment design by generating clinically acceptable plans in a timely and resource-efficient manner. The role of multiple KBP models tailored for variations within a disease site remains undefined in part because of the substantial effort and number of training cases required to create a high-quality KBP model.

Primary Hypertension with Target Organ Damage among Apparently Healthy Secondary School Students in Osogbo, South-Western Nigeria.

Introduction: In recent times, there has been an increase in the frequency of hypertension among young people which is contributing globally to the increase in cardiovascular morbidity and mortality in adults.

Objective: The aim of this study was therefore to determine the prevalence of primary hypertension and its risk factors among apparently healthy secondary school students in Osogbo, southwestern Nigeria.

Methods: A school-based cross-sectional study of a total of 404 secondary school students in Osogbo city.

Comparative analysis of groundwater quality statuses and associated health risk indices of metals and total hydrocarbons at locations of tank farm in Delta State, Nigeria.

The study aimed at assessing the groundwater quality and the associated health implications of oil storage tank farms in Asaba, Oghara, Warri, and Koko towns, in Delta State, Nigeria. Fe, Cr, Cd, Ni, Pb, and V concentrations in the groundwater samples were determined using Atomic Absorption Spectrophotometry (AAS), while total hydrocarbons (THC) concentrations were determined using gas chromatography coupled with a flame ionization detector (GC-FID). The quality index of Warri groundwater was 66.

Geophysical and contamination assessment of soil spatial variability for sustainable precision agriculture in Omu-Aran farm, Northcentral Nigeria.

The spatial and temporal variability of soil properties (fluid composition, structure, and water content) and hydrogeological properties employed for sustainable precision agriculture can be obtained from geoelectrical resistivity methods. For sustainable precision agricultural practices, site-specific information is paramount, especially during the planting season. An integrated one-dimensional (1D) and two-dimensional (2D) electrical resistivity survey have been adopted to characterize the subsoil parameters and delineate the aquifer unit of large farm areas, especially in precision agricultural practices.

Technical note: Determining the applicability of a clinical knowledge-based learning model via prospective outlier detection.

Background: Knowledge-based planning (KBP) is increasingly implemented clinically because of its demonstrated ability to improve treatment planning efficiency and reduce plan quality variations. However, cases with large dose-volume histogram (DVH) prediction uncertainties may still need manual adjustments by the planner to achieve high plan quality.

Purpose: The purpose of this study is to develop a data-driven method to detect patients with high prediction uncertainties so that intentional effort is directed to these patients.

Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats.

Background: Cyclophosphamide (CP) is one of the potent and low cost chemotherapy used in clinical setting against a variety of tumors. However, its association with nephrotoxicity limits its therapeutic use. Ocimum gratissimum leaf is a medicinal plant with numerous pharmacological and therapeutic efficacies, such as antioxidant, anti-inflammation, and anti-apoptotic properties.