Publications by authors named "Kayo Nishitani"
AUTS2 syndrome is characterized by intellectual disability and microcephaly, and is often associated with autism spectrum disorder, but the underlying mechanisms, particularly concerning microcephaly, remain incompletely understood. Here, we analyze mice mutated for the transcriptional regulator AUTS2, which recapitulate microcephaly. Their brains exhibit reduced division of intermediate progenitor cells (IPCs), leading to fewer neurons and decreased thickness in the upper-layer cortex.
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- Normal cells regulate growth and maturation through precise gene expression changes influenced by the epigenome, but the epigenetic shifts during cancer progression are not well-understood.
- This study focuses on medulloblastoma, an embryonal brain tumor, and reveals key epigenomic changes that differentiate precancerous cells from malignant ones.
- It identifies the nuclear factor I (NFIB) transcription factor as a significant player in cancer development, showing that inhibiting NFIB can disrupt the cancer-specific epigenome, highlighting the role of non-mutational mechanisms in tumorigenesis.