Phase II trial of biweekly administration with eribulin after three cycles of induction therapy in hormone receptor-positive, HER2-negative metastatic breast cancer (JACCRO BC-03).

Purpose: Metastatic breast cancer (MBC) is usually incurable; treatment aims to maximize patients' function and quality of life (QOL). Eribulin is a standard treatment in patients with MBC pretreated with anthracycline and taxane; however, the best administration schedule is unknown.

Methods: In this prospective phase II trial of patients with luminal MBC, we administered biweekly eribulin to patients who completed a three-cycle induction treatment.

Risk Profiling of Cancer Treatment-Related Cardiovascular Disorders in Breast Cancer Patients Who Received Adjuvant Chemotherapy With Trastuzumab.

The prognosis of cancer survivors has dramatically improved, but effective strategies for cancer treatment-related cardiovascular disorders (CTRCD) remain to be elucidated in the emerging field of cardio-oncology. In this study, we investigated risk factors for CTRCD in breast cancer patients treated with trastuzumab. We performed a retrospective analysis of 141 consecutive women who received adjuvant trastuzumab, and underwent baseline (BL) and follow-up (FU) echocardiography at Juntendo University between April 2010 and December 2016.

Overcoming the Adverse Effects of Everolimus to Achieve Maximum Efficacy in the Treatment of Inoperable Breast Cancer: A Review of 11 Cases at Our Hospital.

Everolimus is an effective treatment for advanced and/or metastatic breast cancer, especially in hormone receptor-positive cases. However, adverse events have prevented considerable numbers of clinicians from using this drug. Herein, we reviewed our clinical experiences and endeavored to identify patients in whom the benefits of everolimus treatment would outweigh these adverse events.

Effect of telling patients their "spirometric-lung-age" on smoking cessation in Japanese smokers.

Background: Cigarette smoking remains a significant public health problem. However, current treatment programs have not yet succeeded in sufficiently reducing smoking rates. The study aimed to examine whether patients' recognition of "spirometric-lung-age (SLA)" estimated from spirometry data prompts smoking cessation.

Trypophobic Discomfort is Spatial-Frequency Dependent.

Clusters of holes, such as those in a lotus seedpod, induce trypophobic discomfort. Previous research has demonstrated that high-contrast energy at midrange spatial frequencies in images causes trypophobic discomfort. The present study examined the effects on discomfort of eliminating various spatial frequency components from the images to reveal how each spatial frequency contributes to the discomfort.

Cross-cultural validity of the theory of planned behavior for predicting healthy food choice in secondary school students of Inner Mongolia.

Aims: Unhealthy eating behavior is a serious health concern among secondary school students in Inner Mongolia. To predict their healthy food choices and devise methods of correcting unhealthy choices, we sought to confirm the cross-cultural validity of the theory of planned behavior among Inner Mongolian students.

Materials And Methods: A cross-sectional study, conducted between November and December 2014.

Crossmodal Modulation of Spatial Localization by Mimetic Words.

The present study investigated whether aurally presented mimetic words affect the judgment of the final position of a moving object. In Experiment 1, horizontal apparent motion of a visual target was presented, and an auditory mimetic word of "byun" (representing rapid forward motion), "pitari" (representing stop of motion), or "nisahi" (nonsense syllable) was presented via headphones. Observers were asked to judge which of two test stimuli was horizontally aligned with the target.

A case report of using nivolumab for a malignant melanoma patient with rheumatoid arthritis.

The use of antibodies against programmed cell death 1 (PD-1), which block inhibitory T cell checkpoints, is a promising new therapy for advanced malignant melanoma and NSCLC. However, patients with autoimmune diseases were excluded at the clinical trial using such immune checkpoint inhibitor, because of the possibilities to worsen an adverse event of the autoimmune disease. Thus, the efficacy and toxicity of nivolumab using such cases have not been reported yet.

[Immune Checkpoint for a Kidney Cancer and Other Cancers].

Immune checkpoint inhibitors have been getting increasing attention in the field of cancer treatment, resulting in the investigation of numerous drugs and target cancers. Clinical trials of immune checkpoint inhibitors have focused on malignant melanomas and non-small cell lung cancer;however, recently, clinical trials have been carried out for other cancers. To date, 31 phase III clinical trials have been conducted for 13 types of cancer.

Effect of motion coherence on time perception relates to perceived speed.

The present study examined the effect of coherence of moving visual objects on time perception. Participants observed stimuli composed of four line segments moving behind or in front of occluders. The line segments appeared to move either coherently as a diamond outline or incoherently, depending on the occlusion.

Emotion biases voluntary vertical action only with visible cues.

Emotional information influences our bodily experiences according to the space-valence metaphor (positive/negative is up/down). In the present study, we examined whether visible and invisible emotional stimuli could also modulate voluntary action. After observing an emotional image (e.

[Pharmacological Treatment for Bone Metastasis].

An objective of improvement of treatment outcomes of cancer is alleviation of bone metastasis that occurs in many types of cancers. Recently, the guidelines for the diagnosis and treatment of bone metastasis were published by the Japanese Society of Medical Oncology in cooperation with other groups. These guidelines are essentially evidence based for the pharmacological treatment of bone metastasis by using bone modifying agents (BMA).

Post-determined emotion: motor action retrospectively modulates emotional valence of visual images.

Upward and downward motor actions influence subsequent and ongoing emotional processing in accordance with a space-valence metaphor: positive is up/negative is down. In this study, we examined whether upward and downward motor actions could also affect previous emotional processing. Participants were shown an emotional image on a touch screen.

Time-to-contact estimation modulated by implied friction.

The present study demonstrated that friction cues for target motion affect time-to-contact (TTC) estimation. A circular target moved in a linear path with a constant velocity and was gradually occluded by a static rectangle. The target moved with forward and backward spins or without spin.

Weight lifting can facilitate appreciative comprehension for museum exhibits.

Appreciation of exhibits in a museum can be equated to a virtual experience of lives in the contexts originally surrounding the exhibits. Here we focus on the importance of weight information, and hence tested whether experiencing a weight during museum exhibit appreciation affects the beholders' satisfaction and recognition memory for the exhibits. An experiment was performed at a museum exhibiting skeletal preparations of animals.

The difference in speed sequence influences perceived duration.

Perceived duration of a moving stimulus increases with the speed of the motion. However, a recent study found that the perceived duration of a decelerating stimulus was longer than that of an accelerating one, even though their averaged speed was identical (Matthews 2011 Journal of Experimental Psychology: Human Perception and Performance 37 1617-1627). We conducted three experiments to discover how this speed-change-induced time distortion occurs.

Emotional sounds influence vertical vection.

While viewing a large vertically moving sinusoidal luminance grating, the perception of upward self-motion (vection) was modulated by positive sounds (e.g., a baby's laughter).

One's own name distorts visual space.

Here, we demonstrated that one's own name attracts the subjective location of a visual target. We simultaneously presented observers their own name and others' name in the left and right visual fields. A target circle was presented for 53 ms around the center of the display 200 ms after the names disappeared.

Time dilation caused by static images with implied motion.

The present study examined whether implicit motion information from static images influences perceived duration of image presentation. In Experiments 1 and 2, we presented observers with images of a human and an animal character in running and standing postures. The results revealed that the perceived presentation duration of running images was longer than that of standing images.

The role of orientation processing in the scintillating grid illusion.

In the scintillating grid illusion, illusory dark spots are perceived on white patches at the intersections of gray bars. Previous studies have suggested that processing related to the orientation of the bars plays a role in this illusion, but the specific underlying mechanisms are unclear. In the present study, we investigated the role of orientation processing across the intersection in generating the scintillating grid illusion.

Perceived duration of plaid motion increases with pattern speed rather than component speed.

Several studies have shown that visual motion distorts perceived duration: The duration of fast-moving stimuli is judged to be longer than the same duration of stationary or slow-moving stimuli. However, it is still unclear which stages of motion processing are involved in this apparent dilation of the perceived duration. In this study, using a two-dimensional pattern motion of a plaid as a stimulus, we systematically manipulated the speed of pattern and component motions of the plaid to examine which motion information influences the perceived duration of the plaid stimuli.

A feasibility study of zoledronic acid combined with carboplatin/nedaplatin plus paclitaxel in patients with non-small cell lung cancer with bone metastases.

Aims And Background: Although zoledronic acid (ZOL) has been reported to inhibit bone metastasis from lung cancer, the optimum chemotherapy regimen in combination with ZOL has not yet been determined.

Methods And Study Design: Eighteen patients having non-small cell lung cancer (NSCLC) with bone metastasis who received carboplatin/nedaplatin plus paclitaxel combined with ZOL (4 mg every 28 days) were enrolled to investigate the feasibility of this treatment. The efficacy was evaluated by the percentage of patients at 9 months who were receiving radiation therapy, the time to first radiation treatment, and quality of life.

[Pattern goodness and perceptual organization].

The present study examined the relation between the manner of perceptual organization and pattern goodness. We presented regularly arranged dot patterns (Experiment 1) and randomly arranged dot patterns (Experiment 2). In both experiments, the participants were asked to evaluate the goodness of the patterns using a 7-point scale and to encircle the dots in the manner that the participants had organized them.

Temporal course of position shift for a peripheral target.

When a target is presented near a leading cue stimulus, the perceived location of the target is displaced from the cue (attentional repulsion). On the other hand, a memorized target is sometimes mislocalized toward the cue (attentional attraction). The present study aimed at clarifying the temporal relationship between attentional repulsion and attentional attraction.

Sex hormones alter Th1 responses and enhance granuloma formation in the lung.

Background: The lung is one of the sites of granulomatous responses, which are characterized by the recruitment and organization of activated macrophages and lymphocytes. There have been several reports that have shown that some pulmonary granulomatous diseases, such as sarcoidosis and nontuberculous mycobacterial disease, are likely to be characterized by a preponderance in postmenopausal females. Although sex hormones have been shown to play an important role in the regulation of the immune system, the influence of sex hormones on pulmonary granuloma formation is still unclear.