Publications by authors named "Kayo Kunihiro"
Characterization of myosin II regulatory light chain isoforms in HeLa cells.
Cytoskeleton (Hoboken)
December 2015
Article Synopsis
- Myosin II regulatory light chain (MRLC) is a key protein involved in cell contractility and has three isoforms (MRLC1, MRLC2, MRLC3) in humans, with MRLC2 being the most studied.
- Recent research indicates that while all MRLCs are phosphorylated similarly and colocalize together, their functions in cell spreading differ, with MRLC2 and MRLC3 compensating for each other when MRLCs are depleted, but not MRLC1.
- Computer simulations reveal that MRLC1 has a unique structure compared to MRLC2 and MRLC3, suggesting that despite their similarities, these protein isoforms have distinct roles in cellular activities.