Immunoglobulin a suppresses B cell receptor-mediated activation of mouse B cells with differential inhibition of signaling molecules.

Context: We previously reported that monoclonal mouse immunoglobulin (Ig) A, OA-4, attenuates sensitization in mice by suppressing B cell activation.

Objective: Here, it is demonstrated for the first time that mouse IgA inhibits mouse B cell activation under natural conditions (i.e.