Publications by authors named "Kaylynn Genemaras"
Many countries in sub-Saharan Africa have experienced lower COVID-19 caseloads and fewer deaths than countries in other regions worldwide. Under-reporting of cases and a younger population could partly account for these differences, but pre-existing immunity to coronaviruses is another potential factor. Blood samples from Sierra Leonean Lassa fever and Ebola survivors and their contacts collected before the first reported COVID-19 cases were assessed using enzyme-linked immunosorbent assays for the presence of antibodies binding to proteins of coronaviruses that infect humans.
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- The COVID-19 epidemic in the U.S. went largely unnoticed due to a lack of testing, with New Orleans experiencing one of the earliest outbreaks during Mardi Gras.
- Researchers sequenced SARS-CoV-2 genomes in Louisiana and found that the virus had limited diversity, indicating a single introduction led to most early cases.
- The study revealed that SARS-CoV-2 was likely present in New Orleans before Mardi Gras, and the event significantly contributed to the rapid spread of the virus, highlighting the impact of large gatherings on epidemics.
Article Synopsis
- The early COVID-19 outbreak in the U.S. was largely unnoticed due to insufficient testing and prevention measures, particularly noticeable in New Orleans during Mardi Gras.
- Genetic analysis of SARS-CoV-2 in Louisiana revealed that the virus had limited diversity at first and that one initial introduction was responsible for most early transmissions.
- The presence of the virus in New Orleans before Mardi Gras and the festival's large gatherings significantly sped up the spread, contributing to localized epidemics across the Southern U.S.
Decellularized human adipose tissue has potential clinical utility as a processed biological scaffold for soft tissue cosmesis, grafting, and reconstruction. Adipose tissue decellularization has been accomplished using enzymatic-, detergent-, and/or solvent-based methods. To examine the hypothesis that distinct decellularization processes may yield scaffolds with differing compositions, the current study employed mass spectrometry to compare the proteomes of human adipose-derived matrices generated through three independent methods combining enzymatic-, detergent-, and/or solvent-based steps.
View Article and Find Full Text PDFEndothelial surface glycocalyx (ESG) is a carbohydrate-rich, gel-like layer found on vascular endothelium, serving critical functions in mechanotransduction of blood flows, maintenance of the endothelial permeability, and the control of leukocyte adhesion and inflammation. This study aimed to clarify the role of ESG in the adhesion between leukocytes and Human Umbilical Vein Endothelial Cells (HUVECs) under resting or inflammatory conditions. Using an atomic force microscopy-based single-cell adhesion assay, we directly quantified the detachment force and work perpendicular to the cell membrane.
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