Constructing new bonds to carbon in dihydroquinazolines hypervalent iodine(III)-mediated C(sp)-C(sp) bond functionalization.

A hypervalent iodine(III)-mediated C(sp)-C(sp) bond functionalization reaction for the formation of C-C, C-P, and C-H bonds in dihydroquinazolines has been developed. This one-pot method involves successive oxidation of dihydroquinazoline substrates, mesolytic cleavage of a -butyl substituent, and bond formation to a variety of nucleophiles in moderate to high yields.