Publications by authors named "Kaylin Camidge"
Background: Low-dose computed tomography (lung cancer screening) can reduce lung cancer-specific mortality by 20-24%. Based on this evidence, the United States Preventive Services Task Force recommends annual lung cancer screening for asymptomatic high-risk individuals. Despite this recommendation, utilization is low (3-20%).
View Article and Find Full Text PDFMaternal ethanol consumption before paternal fertilization: Stimulation of hypocretin neurogenesis and ethanol intake in zebrafish offspring.
Prog Neuropsychopharmacol Biol Psychiatry
January 2020
There are numerous clinical and pre-clinical studies showing that exposure of the embryo to ethanol markedly affects neuronal development and stimulates alcohol drinking and related behaviors. In rodents and zebrafish, our studies show that embryonic exposure to low-dose ethanol, in addition to increasing voluntary ethanol intake during adolescence, increases the density of hypothalamic hypocretin (hcrt) neurons, a neuropeptide known to regulate reward-related behaviors. The question addressed here in zebrafish is whether maternal ethanol intake before conception also affects neuronal and behavioral development, phenomena suggested by clinical reports but seldom investigated.
View Article and Find Full Text PDFArticle Synopsis
- Embryonic exposure to low-dose ethanol (EtOH) increases the number and alters the migratory patterns of hypocretin/orexin (hcrt) neurons in zebrafish, which are linked to reward-driven behaviors and future alcohol consumption.
- Time-lapse imaging showed that EtOH exposure affected hcrt neuron migration speed and direction, leading to asymmetrical effects primarily on the left side of the brain.
- The changes in hcrt neuron development were persistent, resulting in abnormalities in their final positions, particularly outside their normal area in the anterior hypothalamus, suggesting long-term impacts on neurochemical systems.