Background: A desire for hastened death is commonly expressed by cancer patients. Although efforts to define and explore this issue have been undertaken, no standardized approach exists to address these desires.
* The study analyzed symptom variability using within-subject standard deviation (WS-SD) based on daily questionnaires from participants in the SPIROMICS Exacerbations sub-study, finding that those with higher variability scored worse on quality of life assessments.
* WS-SD is a reliable measure of symptom variability in COPD and indicates that greater variability is linked to poorer health-related quality of life, suggesting it needs further validation for clinical relevance.