Publications by authors named "Kayleigh Oughham"
Clinical outcomes of isolation from neonates, England, 2015-2021: a retrospective case-control study.
Arch Dis Child Fetal Neonatal Ed
February 2024
Objective: , a coagulase-negative staphylococci (CoNS) species, has been increasingly detected from UK sterile site samples and has caused neonatal unit outbreaks worldwide. We compared survival to discharge and 30-day mortality for the detection of versus other CoNS species.
Methods: In this retrospective case-control study, we included hospitalised infants with any CoNS species detected from a normally sterile body site up to 90 days of age.
Background: Parenteral nutrition (PN) is used to provide supplemental support to neonates while enteral feeding is being established. PN is a high-cost intervention with beneficial and harmful effects. Internationally, there is substantial variation in how PN is used, and there are limited contemporary data describing use across Great Britain.
View Article and Find Full Text PDFKernicterus in neonates from ethnic minorities in the UK.
Arch Dis Child Fetal Neonatal Ed
July 2023
Objective: To evaluate the impact of timing of initiation of parenteral nutrition (PN) after birth in very preterm infants.
Design: Propensity-matched analysis of data from the UK National Neonatal Research Database.
Patients: 65 033 babies <31 weeks gestation admitted to neonatal units in England and Wales between 2008 and 2019.
Outcomes in relation to early parenteral nutrition use in preterm neonates born between 30 and 33 weeks' gestation: a propensity score matched observational study.
Arch Dis Child Fetal Neonatal Ed
March 2022
Objective: To evaluate whether in preterm neonates parenteral nutrition use in the first 7 postnatal days, compared with no parenteral nutrition use, is associated with differences in survival and other important morbidities. Randomised trials in critically ill older children show that harms, such as nosocomial infection, outweigh benefits of early parenteral nutrition administration; there is a paucity of similar data in neonates.
Design: Retrospective cohort study using propensity matching including 35 maternal, infant and organisational factors to minimise bias and confounding.
Article Synopsis
- Parenteral nutrition is often used during therapeutic hypothermia for critically ill infants, but studies suggest it could be harmful.
- A retrospective study analyzed data from over 6,000 babies treated with therapeutic hypothermia, comparing those who received parenteral nutrition to those who did not.
- Results showed that while parenteral nutrition was linked to a higher rate of late-onset infections, it also correlated with increased survival rates, highlighting the need for further research to understand these conflicting outcomes.
Objective: To describe temporal changes in inhaled nitric oxide (iNO) use in English neonatal units between 2010 and 2015.
Design: Retrospective analysis using data extracted from the National Neonatal Research Database.
Setting: All National Health Service neonatal units in England.