Publications by authors named "Kayla N Garthus"
Article Synopsis
- The processes involved in bone fracture repair share similarities with the mechanisms of skeletal development during embryonic stages, emphasizing the role of Hox genes in this context.
- Recent research indicates that Hox11 genes, important for limb development, are also active in adult stem cells within the zeugopod skeleton after a fracture occurs.
- Loss of Hox11 function leads to problems in cartilage production and bone remodeling during the healing process, suggesting that these genes are essential for proper fracture repair in adults.
Hox genes are critical regulators of skeletal development and Hox9-13 paralogs, specifically, are necessary for appendicular development along the proximal to distal axis. Loss of function of both Hoxa11 and Hoxd11 results in severe malformation of the forelimb zeugopod. In the radius and ulna of these mutants, chondrocyte development is perturbed, growth plates are not established, and skeletal growth and maturation fails.
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