Publications by Kayla Marie Fantone

Publications by authors named "Kayla Marie Fantone"

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Variant-dependent oxidative and cytokine responses of human neutrophils to SARS-CoV-2 spike protein and anti-spike IgG1 antibodies.

Nathalie Bonatti Franco Almeida Kayla Marie Fantone Demba Sarr Nuha Milad Ashtiwi Sarah Channell

Front Immunol

November 2023

Introduction: Severe forms of COVID-19, the disease caused by SARS-CoV-2, are characterized by acute respiratory distress syndrome, robust lung inflammation and death in some patients. Strong evidence has been accumulating that polymorphonuclear neutrophilic granulocytes (PMN) play an important role in the pathophysiology of severe COVID-19. SARS-CoV-2 directly induces PMN activation, mainly the release of neutrophil extracellular traps (NETs).

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- Kayla Marie Fantone's recent research focuses on the immune response of human neutrophils to SARS-CoV-2, particularly examining how variant-dependent factors influence oxidative and cytokine responses.
- Her study highlights the critical role of polymorphonuclear neutrophils (PMN) in severe COVID-19 cases, emphasizing their activation and involvement in acute respiratory distress syndrome and lung inflammation.
- The findings contribute to understanding the pathophysiology of severe COVID-19, detailing how SARS-CoV-2 leads to PMN activation and the potential implications for therapeutic strategies targeting the immune response.

Publications by authors named "Kayla Marie Fantone"

Variant-dependent oxidative and cytokine responses of human neutrophils to SARS-CoV-2 spike protein and anti-spike IgG1 antibodies.

Synopsis of recent research by authors named "Kayla Marie Fantone"