Publications by authors named "Kayla Livingston"
Monitoring new mutations in SARS-CoV-2 provides crucial information for identifying diagnostic and therapeutic targets and important insights to achieve a more effective COVID-19 control strategy. Next generation sequencing (NGS) technologies have been widely used for whole genome sequencing (WGS) of SARS-CoV-2. While various NGS methods have been reported, one chief limitation has been the complexity of the workflow, limiting the scalability.
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- The study focused on a new non-invasive prenatal screening (NIPS) test for detecting fetal aneuploidies using advanced sequencing techniques and automated processes.
- Validation of the test involved thousands of maternal plasma samples, leading to effective discrimination between affected (autosomal trisomy) and unaffected pregnancies.
- Positive predictive values (PPVs) were significantly high, at 98% for trisomy 21, 92% for trisomy 18, and 69% for trisomy 13, with improvements noted after addressing false-positive causes.