Publications by authors named "Kayla L Metzger"
Most depressed patients don't respond to their first drug treatment, and the reasons for this treatment resistance remain enigmatic. Human studies implicate a polymorphism in the promoter of the serotonin-1A (5-HT(1A)) receptor gene in increased susceptibility to depression and decreased treatment response. Here we develop a new strategy to manipulate 5-HT(1A) autoreceptors in raphe nuclei without affecting 5-HT(1A) heteroreceptors, generating mice with higher (1A-High) or lower (1A-Low) autoreceptor levels.
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- Medication adherence is a major public health challenge in treating severe psychiatric disorders like schizophrenia, leading to the exploration of new treatment methods, such as implantable medication delivery systems.
- A study evaluated the attitudes of psychiatric patients and their families towards these implantable systems, including individuals with schizophrenia and mood disorders.
- Results show significant support for the implantable option, with nearly half of the patients and over 74% of family members expressing acceptance, suggesting it could be a viable alternative to traditional medication methods.
Rationale: Non-adherence with medication remains the major correctable cause of poor outcome in schizophrenia. However, few treatments have addressed this major determinant of outcome with novel long-term delivery systems.
Objectives: The aim of this study was to provide biological proof of concept for a long-term implantable antipsychotic delivery system in rodents and rabbits.
Background: Schizophrenia patients display sensory processing deficits, reduced alpha7-nicotine receptor expression, and increased incidence of smoking, prompting investigation of nicotine receptor agonists as possible treatments. We evaluated the effects of acute and chronic nicotine, using an animal model that incorporates genetic variation for sensory processing and nicotine sensitivity.
Methods: C57BL/6J and DBA/2Hsd mice received 2 weeks of 4.