Reproductive Ageing: Declining translational capacity as a potential driver for oocyte meiotic instability.

In Brief: This point of view article focuses on the potential contribution of defects in protein synthesis (translation) to the incidence of oocyte meiotic failure. We discuss the potential cause of diminished oocyte translation during aging and the impact of these deficits on the function of the meiotic spindle.

Abstract: Errors during female meiosis lead to embryonic aneuploidy and miscarriage and occur with increasing frequency during aging.