Publications by authors named "Kayla Gaete"
The common cold coronaviruses are a source of ongoing morbidity and mortality particularly among elderly and immunocompromised individuals. While cross-reactive immune responses against multiple coronaviruses have been described following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination, it remains unclear if these confer any degree of cross-protection against the common cold coronaviruses. A recombinant fowl adenovirus vaccine expressing the SARS-CoV-2 spike protein (FAdV-9-S19) was generated, and protection from SARS-CoV-2 challenge was shown in K18-hACE2 mice.
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- - The study analyzed data from 30 patients with laboratory-confirmed Creutzfeldt-Jakob disease (CJD) at three Ontario hospitals between 2012 and 2022, revealing specific epidemiology trends and diagnostic timelines in this region.
- - Patients exhibited key symptoms like loss of coordination and memory loss, with an average delay of 91 days from symptom onset to testing, and MRI and EEG results supported the diagnosis in most cases.
- - After diagnosis, a significant number of patients faced poor outcomes, with an average of 121 days from symptom onset to death, emphasizing the need for quicker identification and testing of CJD symptoms.
Article Synopsis
- Long COVID is characterized by persistent symptoms after initial COVID-19 infection, and understanding its early mechanisms may help in developing preventive treatments.
- Analyzing samples from those infected reveals 26 upregulated genes and dysregulated pathways related to immune response and neurotransmission, indicating significant differences between long COVID and non-long COVID patients.
- Identifying these early gene pathway abnormalities could aid in the early diagnosis of long COVID and highlight a critical period for intervention following acute infection.
Introduction: The on-going substance use crisis has led to unprecedented rates of hepatitis C virus (HCV) in Canada, with increasing positivity among women who use drugs (WWUD). Despite efforts to reduce barriers to HCV testing and treatment, follow-up remains a major issue.
Methods: In this quality improvement project (QIP), we partnered with a short-stay trauma-informed residential drug treatment facility specifically for WWUD, to provide an engaging peer-led HCV education session, followed by low-barrier nurse and peer-led testing and treatment.