Impact of Tacrolimus Trough Variability on Acute Rejection Following Lung Transplantation.

Background: Acute rejection is a risk factor for the development of chronic lung allograft dysfunction, the leading cause of morbidity and mortality in lung transplant recipients. Calcineurin inhibitors are the cornerstone of immunosuppression regimens after lung transplantation.

Methods: We retrospectively evaluated the association of tacrolimus level variability with total acute rejection score at 12 months post-transplant.