Ameliorative effects of thymoquinone on the caspase 3, kidney function and oxidative stress tartrazine-induced nephrotoxicity.

First in the literature this study aimed to investigate the effects of Tartrazine, a common industrial food dye, on kidney and whether Thymoquinone has a protective effect in tartrazine-induced nephrotoxicity. The study conducted on the rats bred at İnönü University Experimental Animals Production and Research Center. Wistar albino rats were randomly divided into 4 groups, where each group included 8 rats: control, Tartrazine, Thymoquinone, and Tartrazine + Thymoquinone groups.

High-fat and carbohydrate diet caused chronic kidney damage by disrupting kidney function, caspase-3, oxidative stress and inflammation.

The study aimed to compare the effects of a diet rich in fat, carbohydrates and protein on rat kidneys. The study was conducted on 40 Wistar albino rats bred at İnönü University Faculty of Medicine after the approval of the ethics committee. Rats were randomly divided into 4 groups: Control group, and the groups where the animals were fed with high carbohydrate, fat and protein rich feed.

Mother-infant social gaze dynamics relate to infant brain activity and word segmentation.

The 'social brain', consisting of areas sensitive to social information, supposedly gates the mechanisms involved in human language learning. Early preverbal interactions are guided by ostensive signals, such as gaze patterns, which are coordinated across body, brain, and environment. However, little is known about how the infant brain processes social gaze in naturalistic interactions and how this relates to infant language development.

A cellulose-based material as a fluorescent sensor for Cr(VI) detection and investigation of antimicrobial properties of its encapsulated form in two different MOFs.

It is crucial to detect toxic chromium ions quickly, reliably, sensitively and at low concentrations. In recent years, fluorescence-based methods have been developed for the rapid detection and determination of toxic ions such as chromium. In present work, we focused on the development of a cellulose-based fluorescent probe (Cel-Nap) for the determination of Cr(VI).

Visual category representations in the infant brain.

Visual categorization is a human core cognitive capacity that depends on the development of visual category representations in the infant brain. However, the exact nature of infant visual category representations and their relationship to the corresponding adult form remains unknown. Our results clarify the nature of visual category representations from electroencephalography (EEG) data in 6- to 8-month-old infants and their developmental trajectory toward adult maturity in the key characteristics of temporal dynamics, representational format, and spectral properties.

The role of mother-infant emotional synchrony in speech processing in 9-month-old infants.

Rhythmicity characterizes both interpersonal synchrony and spoken language. Emotions and language are forms of interpersonal communication, which interact with each other throughout development. We investigated whether and how emotional synchrony between mothers and their 9-month-old infants relates to infants' word segmentation as an early marker of language development.

Interpersonal neural synchrony when predicting others' actions during a game of rock-paper-scissors.

As members of a social species, we spend most of our time interacting with others. In interactions, we tend to mutually align our behavior and brain responses to communicate more effectively. In a semi-computerized version of the Rock-Paper-Scissors game, we investigated whether people show enhanced interpersonal neural synchronization when making explicit predictions about others' actions.

DEEP: A dual EEG pipeline for developmental hyperscanning studies.

Cutting-edge hyperscanning methods led to a paradigm shift in social neuroscience. It allowed researchers to measure dynamic mutual alignment of neural processes between two or more individuals in naturalistic contexts. The ever-growing interest in hyperscanning research calls for the development of transparent and validated data analysis methods to further advance the field.

Enhancing reproducibility in developmental EEG research: BIDS, cluster-based permutation tests, and effect sizes.

Developmental research using electroencephalography (EEG) offers valuable insights in brain processes early in life, but at the same time, applying this sensitive technique to young children who are often non-compliant and have short attention spans comes with practical limitations. It is thus of particular importance to optimally use the limited resources to advance our understanding of development through reproducible and replicable research practices. Here, we describe methodological approaches that help maximize the reproducibility of developmental EEG research.

An Embodied Cognition Perspective on the Role of Interoception in the Development of the Minimal Self.

Interoception is an often neglected but crucial aspect of the human minimal self. In this perspective, we extend the embodiment account of interoceptive inference to explain the development of the minimal self in humans. To do so, we first provide a comparative overview of the central accounts addressing the link between interoception and the minimal self.

Keeping the Breath in Mind: Respiration, Neural Oscillations, and the Free Energy Principle.

Scientific interest in the brain and body interactions has been surging in recent years. One fundamental yet underexplored aspect of brain and body interactions is the link between the respiratory and the nervous systems. In this article, we give an overview of the emerging literature on how respiration modulates neural, cognitive and emotional processes.

Effects of Reinforcement Learning on Gaze Following of Gaze and Head Direction in Early Infancy: An Interactive Eye-Tracking Study.

The current four experiments investigated gaze following behavior in response to gaze and head turns in 4-month-olds and how reinforcement learning influences this behavior (N = 99). Using interactive eye tracking, infants' gaze elicited an animation whenever infants followed a person's head or gaze orientation (Experiment 1.1, 2.

Interpersonal Neural Synchrony During Father-Child Problem Solving: An fNIRS Hyperscanning Study.

Interpersonal neural synchrony (INS) has been previously evidenced in mother-child interactions, yet findings concerning father-child interaction are wanting. The current experiment examined whether fathers and their 5- to 6-year-old children (N = 66) synchronize their brain activity during a naturalistic interaction, and addressed paternal and child factors related to INS. Compared to individual problem solving and rest, father-child dyads showed increased INS in bilateral dorsolateral prefrontal cortex and left temporo-parietal junction during cooperative problem solving.

Neural synchrony in mother-child conversation: Exploring the role of conversation patterns.

Conversations are an essential form of communication in daily family life. Specific patterns of caregiver-child conversations have been linked to children's socio-cognitive development and child-relationship quality beyond the immediate family environment. Recently, interpersonal neural synchronization has been proposed as a neural mechanism supporting conversation.

Making Sense of the World: Infant Learning From a Predictive Processing Perspective.

For human infants, the first years after birth are a period of intense exploration-getting to understand their own competencies in interaction with a complex physical and social environment. In contemporary neuroscience, the predictive-processing framework has been proposed as a general working principle of the human brain, the optimization of predictions about the consequences of one's own actions, and sensory inputs from the environment. However, the predictive-processing framework has rarely been applied to infancy research.

The molecular targets of diclofenac differs from ibuprofen to induce apoptosis and epithelial mesenchymal transition due to alternation on oxidative stress management p53 independently in PC3 prostate cancer cells.

Background: Prostate cancer is the most common type of cancer among men. Studies showed that the regular use of nonsteroidal antiinflammatory drugs might reduce disease progression risk for prostate cancer patients with prostate cancer. We evaluated the effects of ectopic expression of p53 on the biological functions of ibuprofen and diclofenac.

The effects of interaction quality on neural synchrony during mother-child problem solving.

Understanding others is fundamental to interpersonal coordination and successful cooperation. One mechanism posited to underlie both effective communication and behavioral coordination is interpersonal neural synchrony. Although presumably foundational for children's social development, research on neural synchrony in naturalistic caregiver-child interactions is lacking.

Nine-month-old infants update their predictive models of a changing environment.

Humans generate internal models of their environment to predict events in the world. As the environments change, our brains adjust to these changes by updating their internal models. Here, we investigated whether and how 9-month-old infants differentially update their models to represent a dynamic environment.

Young children integrate current observations, priors and agent information to predict others' actions.

From early on in life, children are able to use information from their environment to form predictions about events. For instance, they can use statistical information about a population to predict the sample drawn from that population and infer an agent's preferences from systematic violations of random sampling. We investigated whether and how young children infer an agent's sampling biases.

Infants differentially update their internal models of a dynamic environment.

Unexpected events provide us with opportunities for learning about what to expect from the world around us. Using a saccadic-planning paradigm, we investigated whether and how infants and adults represent the statistics of a changing environment (i.e.

Infants Distinguish Between Two Events Based on Their Relative Likelihood.

Likelihood estimations are crucial for dealing with the uncertainty of life. Here, infants' sensitivity to the difference in likelihood between two events was investigated. Infants aged 6, 12, and 18 months (N = 75) were shown animated movies of a machine simultaneously drawing likely and unlikely samples from a box filled with different colored balls.

Developing the residential environment impact survey instruments through faculty-practitioner collaboration.

The Residential Environment Impact Survey (REIS) and the REIS-Short Form (REIS-SF), based on the Model of Human Occupation, are non-standardized, semi-structured assessments aimed at evaluating how a home influences the quality of life of the resident(s). Occupational therapy practitioners have used these instruments as consulting tools to formulate and implement recommendations to improve residents' occupational functioning. Using a faculty-practitioner collaboration framework, international REIS and REIS-SF users were surveyed to elicit feedback regarding how these tools are being used, and how they can be improved.

Synthesis, characterization, electronic and gas-sensing properties towards H2 and CO of transparent, large-area, low-layer graphene.

Low-layered, transparent graphene is accessible by a chemical vapor deposition (CVD) technique on a Ni-catalyst layer, which is deposited on a <100> silicon substrate. The number of graphene layers on the substrate is controlled by the grain boundaries in the Ni-catalyst layer and can be studied by micro Raman analysis. Electrical studies showed a sheet resistance (R(sheet)) of approximately 1435 Ω per □, a contact resistance (R(c)) of about 127 Ω, and a specific contact resistance (R(sc)) of approximately 2.