Publications by authors named "Kaya Saskia Bittkau"
Article Synopsis
- - The study evaluated the effects of a brown seaweed extract (DF) on two types of cancer: glioblastoma and uveal melanoma, to explore its potential as an anti-cancer treatment.
- - Cell viability, proliferation rates, and VEGF (vascular endothelial growth factor) secretion were measured across various human cell types, revealing that DF reduced viability and proliferation in certain cancer cells while affecting VEGF levels differently depending on the cell type.
- - Although results for glioblastoma weren't promising, the extract showed potential anti-tumor effects in uveal melanoma cells, indicating a need for further research in treating eye-related cancers.
We hypothesized that, in mice, histamine via the histamine receptor subtype 4 (HR) on colon epithelial cells affects epithelial barrier integrity, perturbing physiologic function of the colonic mucosa and thus aggravating the severity of colitis. To test this hypothesis, bone marrow-chimeric mice were generated from HR knockout (HR) and wild-type (WT) BALB/cJ mice and subjected to the dextrane sodium sulfate (DSS)-induced acute colitis model. Clinical symptoms and pathohistological derangements were scored.
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- Fucoidans are a type of sulfated polysaccharides containing fucose, and their biological activities are influenced by factors like sulfation degree, molecular weight distribution, and chain structure.
- Recent advancements in NMR and mass spectrometry techniques provide insights into glycan structures, but full understanding of fucoidans in their natural state remains limited.
- The study examined six different fucoidans using advanced size exclusion chromatography, revealing significant variations in their molecular weight profiles and suggesting they generally exist as flexible branched structures in solution, which aids in understanding their bioactivities.
Fucoidan extracts may have beneficial effects in age-related macular degeneration(AMD). Over-the-counter fucoidan preparations are generally undefined, crude extracts. In thisstudy, we investigated the effect of a crude fucoidan extract from subspeciesevanescens (Fe) on the retinal pigment epithelium (RPE).
View Article and Find Full Text PDFFucoidans extracted from brown algae exert manifold biological activities paving the way for the development of numerous applications including treatments outside tumor therapy such as age-related macular degeneration or tissue engineering. In this study, we investigated the antiproliferative effects of fucoidans extracted from six different algae ( subsp ) as well as three reference compounds (Sigma fucoidan, heparin, enoxaparin) on tumor (HL-60, Raji, HeLa, OMM-1, A-375, HCT-116, Hep G2) and non-tumor (ARPE-19, HaCaT cell lines. All fucoidans were extracted according to a standardized procedure and tested in a commercially available MTS assay.
View Article and Find Full Text PDFBackground: Fucoidans are interesting for potential usage in ophthalmology, and especially age-related macular degeneration. However, fucoidans from different species may vary in their effects. Here, we compare fucoidans from five algal species in terms of oxidative stress protection and vascular endothelial growth factor (VEGF) interference in ocular cells.
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